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dc.contributor.authorRay, Subarna
dc.contributor.authorTa, Hang T
dc.date.accessioned2020-07-30T01:34:06Z
dc.date.available2020-07-30T01:34:06Z
dc.date.issued2020
dc.identifier.issn2079-4983
dc.identifier.doi10.3390/jfb11030051
dc.identifier.urihttp://hdl.handle.net/10072/395904
dc.description.abstractPoly-l-lactic acid (PLLA), a synthetic, biocompatible, biodegradable polymer, has been safely used in several clinical applications in recent decades. Typically, SculptraTM, the commercially injectable PLLA in the form of microparticles, has been used as facial volumizer in the treatment of lipoatrophy in HIV patients. It also has various applications in tissue engineering by improving cell proliferation and adhesion. Sculptra™ can be categorised as a stimulatory filler as it stimulates the synthesis and deposition of fibrous tissue and collagen. Collagen is one of the most significant components of the extracellular matrix and beneficial for the normal physiology. It is also the structural component of a human body. In most of the studies, the effect of Sculptra on collagen synthesis was investigated in vivo and the majority of the data were from clinical and histological reports. There is only one study reporting this effect in vitro using fibroblasts. Here, we investigated whether PLLA in the form of nanoparticles can provide the same effect on collagen synthesis in fibroblasts as Sculptra. We surprisingly found that there was no stimulation of collagen in fibroblasts alone, whereas the co-cultures of fibroblast and macrophage had shown collagen stimulation by PLLA nanoparticles. It is also confirmed that collagen synthesis was caused by fibroblasts but not macrophages. Although further study needs to be conducted to evaluate its mechanism, our findings showed that choosing an appropriate method is essential for investigating the effect of PLLA or other biomaterials on collagen synthesis by fibroblasts in vitro.
dc.description.peerreviewedYes
dc.description.sponsorshipNational Heart Foundation of Australia
dc.languageeng
dc.publisherMultidisciplinary Digital Publishing Institute
dc.relation.ispartofpagefrom51
dc.relation.ispartofpageto51
dc.relation.ispartofissue3
dc.relation.ispartofjournalJournal of Functional Biomaterials
dc.relation.ispartofvolume11
dc.relation.urihttp://purl.org/au-research/grants/NHMRC/APP1146694
dc.relation.grantIDAPP1146694
dc.relation.fundersNHMRC
dc.subject.fieldofresearchBiomedical Engineering
dc.subject.fieldofresearchMedical Biotechnology
dc.subject.fieldofresearchcode0903
dc.subject.fieldofresearchcode1004
dc.titleInvestigating the Effect of Biomaterials Such as Poly-(l-Lactic Acid) Particles on Collagen Synthesis In Vitro: Method Is Matter
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationRay, S; Ta, HT, Investigating the Effect of Biomaterials Such as Poly-(l-Lactic Acid) Particles on Collagen Synthesis In Vitro: Method Is Matter, Journal of Functional Biomaterials, 11 (3), pp. 51-51
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-07-24T23:05:50Z
dc.description.versionPublished
gro.rights.copyright© 2020 The Authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
gro.hasfulltextFull Text
gro.griffith.authorTa, Hang


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