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dc.contributor.authorRuhee, Ruheea Taskin
dc.contributor.authorRoberts, Llion Arwyn
dc.contributor.authorMa, Sihui
dc.contributor.authorSuzuki, Katsuhiko
dc.date.accessioned2020-07-30T05:26:23Z
dc.date.available2020-07-30T05:26:23Z
dc.date.issued2020
dc.identifier.issn2296-861X
dc.identifier.doi10.3389/fnut.2020.00064
dc.identifier.urihttp://hdl.handle.net/10072/395947
dc.description.abstractPhytonutrients are widely recognized for providing protective human health benefits. Among the phytonutrients, epidemiological and experimental studies show that dietary organosulfur compounds (OSC) play a significant role in preventing various human pathological progressions, including chronic inflammation, by decreasing inflammatory mediators such as nitric oxide (NO), prostaglandin (PG)E2, interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and IL-17, which are all typical hallmarks of inflammation. Evidence supports OSC in reducing the expression of these markers, thereby attenuating chronic inflammatory processes. Nuclear factor-kappa B (NF-κB) is a key regulating factor during inflammation, and novel evidence shows that OSC downregulates this transcriptional factor, thus contributing to the anti-inflammatory response. In vitro and in vivo studies show that inflammation is mechanistically linked with acute and chronic pathological conditions including cancer, diabetes, obesity, neural dysfunction, etc. Furthermore, a considerable number of experiments have demonstrated that the anti-inflammatory properties of OSC occur in a dose-dependent manner. These experiments also highlight indirect mechanisms as well as potent co-functions for protective roles as antioxidants, and in providing chemoprotection and neuroprotection. In this brief review, we provided an overview of the anti-inflammatory effects of OSC and elucidated probable mechanisms that are associated with inflammation and chronic disorders.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherFrontiers Media SA
dc.relation.ispartofjournalFrontiers in Nutrition
dc.relation.ispartofvolume7
dc.subject.fieldofresearchNutrition and Dietetics
dc.subject.fieldofresearchAgricultural Biotechnology
dc.subject.fieldofresearchcode1111
dc.subject.fieldofresearchcode1001
dc.subject.keywordsNF-κB
dc.subject.keywordschronic diseases
dc.subject.keywordscytokines
dc.subject.keywordsinflammation
dc.subject.keywordsorganosulfur compounds
dc.titleOrganosulfur Compounds: A Review of Their Anti-inflammatory Effects in Human Health
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationRuhee, RT; Roberts, LA; Ma, S; Suzuki, K, Organosulfur Compounds: A Review of Their Anti-inflammatory Effects in Human Health., Frontiers in Nutrition, 2020, 7, article 64
dcterms.dateAccepted2020-04-20
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-07-27T22:50:33Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020 Ruhee, Roberts, Ma and Suzuki. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
gro.hasfulltextFull Text
gro.griffith.authorRoberts, Llion A.


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