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dc.contributor.authorde Zoete, RMJ
dc.contributor.authorChen, K
dc.contributor.authorSterling, M
dc.date.accessioned2020-07-31T00:34:59Z
dc.date.available2020-07-31T00:34:59Z
dc.date.issued2020
dc.identifier.issn2044-6055
dc.identifier.doi10.1136/bmjopen-2019-036151
dc.identifier.urihttp://hdl.handle.net/10072/395976
dc.description.abstractOBJECTIVE: Primary objectives: to investigate the central neurobiological effects (using MRI) of physical exercise in individuals with chronic pain. Secondary objectives: (1) to investigate the associations between central changes and clinical outcomes and (2) to investigate whether different types and dosages of physical exercise exert different central changes. DESIGN: Systematic review searching four electronic databases up to September 2018: AMED, CINAHL, Embase and MEDLINE. Two reviewers independently assessed the methodological quality of included studies using the Cochrane Collaboration's Risk of Bias in Non-Randomised Studies-I tool. A standardised extraction table was used for data extraction, which was performed by two reviewers. INTERVENTIONS: Studies reporting any physical exercise intervention in any chronic musculoskeletal pain condition were included. Eligibility of 4011 records was screened independently by two reviewers, and four studies were included in the review. PRIMARY AND SECONDARY OUTCOME MEASURES: Primary outcome: any brain outcome assessed with any MR technique. SECONDARY OUTCOMES: any self-reported clinical outcomes, and type and dosage of the exercise intervention. RESULTS: All four studies had high risk of bias. There was heterogeneity between the brain areas studied and the types of exercise interventions delivered. All studies reported functional MRI changes in various brain areas following an exercise intervention. Insufficient data were available to conduct a meta-analysis or to answer the secondary aims. CONCLUSIONS: Only a limited number of studies were available and all were at high risk of bias. None of the studies was randomised or included blinded assessment. Exercise may exert effects on brain neurobiology in people with chronic pain. Due to the high risk of bias, future studies should use a randomised study design. Investigation of morphological brain changes could be included. PROSPERO REGISTRATION NUMBER: CRD42018108179.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBMJ
dc.relation.ispartofpagefrome036151
dc.relation.ispartofissue7
dc.relation.ispartofjournalBMJ open
dc.relation.ispartofvolume10
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchOther Medical and Health Sciences
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1117
dc.subject.fieldofresearchcode1199
dc.subject.keywordsmagnetic resonance imaging
dc.subject.keywordsmusculoskeletal disorders
dc.subject.keywordsneuroradiology
dc.subject.keywordspain management
dc.subject.keywordsrehabilitation medicine
dc.titleCentral neurobiological effects of physical exercise in individuals with chronic musculoskeletal pain: a systematic review
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationde Zoete, RMJ; Chen, K; Sterling, M, Central neurobiological effects of physical exercise in individuals with chronic musculoskeletal pain: a systematic review, BMJ open, 2020, 10 (7), pp. e036151
dcterms.licensehttp://creativecommons.org/licenses/by-nc/4.0/
dc.date.updated2020-07-30T00:55:47Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© Author(s) (or their employer(s)) 2020. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
gro.hasfulltextFull Text
gro.griffith.authorSterling, Michele


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