Show simple item record

dc.contributor.authorWashington, M Kay
dc.contributor.authorGoldberg, Richard M
dc.contributor.authorChang, George J
dc.contributor.authorLimburg, Paul
dc.contributor.authorLam, Alfred K
dc.contributor.authorSalto-Tellez, Manuel
dc.contributor.authorArends, Mark J
dc.contributor.authorNagtegaal, Iris D
dc.contributor.authorKlimstra, David S
dc.contributor.authorRugge, Massimo
dc.contributor.authorSchirmacher, Peter
dc.contributor.authorLazar, Alexander J
dc.contributor.authorOdze, Robert D
dc.contributor.authorCarneiro, Fatima
dc.contributor.authoret al.
dc.date.accessioned2020-07-31T03:46:57Z
dc.date.available2020-07-31T03:46:57Z
dc.date.issued2020
dc.identifier.issn1097-0215
dc.identifier.doi10.1002/ijc.33210
dc.identifier.urihttp://hdl.handle.net/10072/396002
dc.description.abstractThe WHO Classification of Tumours provides the international standards for the classification and diagnosis of tumours. It enables direct comparisons to be made between different countries. In the new 5th Edition, the series has gone digital with the launch of a website as well as a series of books, known widely as the WHO Blue Books. The first volume to be produced is on the classification of Digestive System tumours, replacing the successful 2010 version. It has been rewritten and updated accordingly. This article summarises the major diagnostic innovations that have occurred over the last decade and that have now been incorporated in the classification. As an example, it incorporates the recently proposed classification of neuroendocrine tumours, based on the recognition that neuroendocrine tumours and carcinomas differ substantially in the genetic abnormalities that drive their growth, findings relevant to treatment selection and outcome prediction. Several themes have emerged during the production process. One is the importance of the progression from hyperplasia to dysplasia to carcinoma in the evolution of the malignant process. Advances in imaging techniques and endoscopy have resulted in enhanced access to precancerous lesions in the gastrointestinal and biliary tract, necessitating both changes in classification schema and clinical practice. Diagnosis of tumours is no longer the sole purview of pathologists, and some patients now receive treatment before tissue is obtained, based on clinical, radiological, and liquid biopsy results. This makes the classification relevant to many disciplines involved in the care of patients with tumours of the digestive system.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofjournalInternational Journal of Cancer
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode1112
dc.subject.keywordsDigestive system
dc.subject.keywordsclassification
dc.subject.keywordsdiagnosis
dc.subject.keywordsneoplasms
dc.subject.keywordsneuroendocrine
dc.titleDiagnosis of Digestive System Tumours
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationWashington, MK; Goldberg, RM; Chang, GJ; Limburg, P; Lam, AK; Salto-Tellez, M; Arends, MJ; Nagtegaal, ID; Klimstra, DS; Rugge, M; Schirmacher, P; Lazar, AJ; Odze, RD; Carneiro, F; et al., Diagnosis of Digestive System Tumours, International Journal of Cancer, 2020
dcterms.dateAccepted2020-06-11
dc.date.updated2020-07-31T03:32:21Z
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.rights.copyright© 2020 UICC. This is the peer reviewed version of the following article: Diagnosis of Digestive System Tumours, International Journal of Cancer, 2020, which has been published in final form at DOI. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
gro.hasfulltextFull Text
gro.griffith.authorLam, Alfred K.


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record