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dc.contributor.authorAkpe, Victor
dc.contributor.authorKim, Tak H
dc.contributor.authorBrown, Christopher L
dc.contributor.authorCock, Ian E
dc.date.accessioned2020-08-04T04:37:00Z
dc.date.available2020-08-04T04:37:00Z
dc.date.issued2020
dc.identifier.issn1742-5689
dc.identifier.doi10.1098/rsif.2020.0065
dc.identifier.urihttp://hdl.handle.net/10072/396040
dc.description.abstractCirculating tumour cells (CTCs) have recently been identified as valuable biomarkers for diagnostic and prognostic evaluations, as well for monitoring therapeutic responses to treatments. CTCs are rare cells which may be present as one CTC surrounded by approximately 1 million white blood cells and 1 billion red blood cells per millilitre of peripheral blood. Despite the various challenges in CTC detection, considerable progress in detection methods have been documented in recent times, particularly for methodologies incorporating nanomaterial-based platforms and/or integrated microfluidics. Herein, we summarize the importance of CTCs as biological markers for tumour detection, highlight their mechanism of cellular invasion and discuss the various challenges associated with CTC research, including vulnerability, heterogeneity, phenotypicity and size differences. In addition, we describe nanomaterial agents used for electrochemistry and surface plasmon resonance applications, which have recently been used to selectively capture cancer cells and amplify signals for CTC detection. The intrinsic properties of nanomaterials have also recently been exploited to achieve photothermal destruction of cancer cells. This review describes recent advancements and future perspectives in the CTC field.
dc.description.peerreviewedYes
dc.languageen
dc.publisherThe Royal Society
dc.relation.ispartofissue168
dc.relation.ispartofjournalJournal of The Royal Society Interface
dc.relation.ispartofvolume17
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchEnvironmental Biotechnology
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1002
dc.titleCirculating tumour cells: a broad perspective
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationAkpe, V; Kim, TH; Brown, CL; Cock, IE, Circulating tumour cells: a broad perspective, Journal of The Royal Society Interface, 2020, 17 (168)
dc.date.updated2020-08-02T01:31:43Z
dc.description.versionPost-print
gro.rights.copyright© 2020 Royal Society. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorKim, Tak H.
gro.griffith.authorBrown, Chris L.
gro.griffith.authorCock, Ian E.
gro.griffith.authorAkpe, Victor


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