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dc.contributor.authorOliveira, Katia M
dc.contributor.authorPeterson, Erica J
dc.contributor.authorCarroccia, Murilo C
dc.contributor.authorCominetti, Marcia R
dc.contributor.authorDeflon, Victor M
dc.contributor.authorFarrell, Nicholas P
dc.contributor.authorBatista, Alzir A
dc.contributor.authorCorrea, Rodrigo S
dc.date.accessioned2020-08-03T02:08:30Z
dc.date.available2020-08-03T02:08:30Z
dc.date.issued2020
dc.identifier.issn1477-9234
dc.identifier.doi10.1039/d0dt01091j
dc.identifier.urihttp://hdl.handle.net/10072/396057
dc.description.abstractSix new ruthenium(ii) complexes with lapachol (Lap) and lawsone (Law) with the general formula [Ru(L)(P-P)(bipy)]PF6, where L = Lap or Law, P-P = 1,2'-bis(diphenylphosphino)ethane (dppe), 1,4'-bis(diphenylphosphino)butane (dppb), 1,1'-bis(diphenylphosphino)ferrocene (dppf) and bipy = 2,2'-bipyridine, were synthesized, fully characterized by elemental analysis, molar conductivity, NMR, cyclic voltammetry, UV-vis, IR spectroscopies and three of them by X-ray crystallography. All six complexes were active against breast (MCF-7 and MDA-MB-231) and prostate (DU-145) cancer cell lines with lower IC50 values than cisplatin. Complex [Ru(Lap)(dppe)(bipy)]PF6 (1a) showed significant selectivity for MDA-MB-231, a model of triple-negative breast cancer (TNBC), as compared to the "normal-like" human breast epithelial cell line, MCF-10A. Complex (1a) inhibited TNBC colony formation and induced loss of cellular adhesion. Furthermore, the complex (1a) induced mitochondrial dysfunction and generation of ROS, as is involved in the apoptotic cell death pathway. Preferential cellular uptake of complex (1a) was observed in MDA-MB-231 cells compared to MCF-10A cells, consistent with the observed selectivity for tumorigenic vs. non-tumorigenic cells. Taken together, these results indicate that ruthenium complexes containing lapachol and lawsone as ligands are promising candidates as chemotherapeutic agents.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherRoyal Society of Chemistry (RSC)
dc.relation.ispartofjournalDalton Transactions
dc.subject.fieldofresearchInorganic chemistry
dc.subject.fieldofresearchTheoretical and computational chemistry
dc.subject.fieldofresearchOther chemical sciences
dc.subject.fieldofresearchcode3402
dc.subject.fieldofresearchcode3407
dc.subject.fieldofresearchcode3499
dc.titleRu(ii)-Naphthoquinone complexes with high selectivity for triple-negative breast cancer
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationOliveira, KM; Peterson, EJ; Carroccia, MC; Cominetti, MR; Deflon, VM; Farrell, NP; Batista, AA; Correa, RS, Ru(ii)-Naphthoquinone complexes with high selectivity for triple-negative breast cancer, Dalton Transactions, 2020
dc.date.updated2020-08-03T02:07:22Z
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.hasfulltextNo Full Text
gro.griffith.authorFarrell, Nicholas


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