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  • Acquired Immunodeficiency from Maternal Chemotherapy and Severe Primary Pneumocystis Infection in an Infant

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    Author(s)
    Lim, Adeline Yi Ling
    Mattke, Adrian Christian
    Clark, Julia Elizabeth
    Pinzon-Charry, Alberto
    Alphonso, Nelson
    Kapur, Nitin
    Griffith University Author(s)
    Pinzon-Charry, Alberto
    Year published
    2020
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    Abstract
    Pneumocystis jirovecii is recognized as an opportunistic pathogen in immunosuppressed patients. We report a case of severe Pneumocystis pneumonia (PCP) in an infant with acquired combined immunodeficiency secondary to maternal chemotherapy exposure during the second and third trimesters of pregnancy. The infant required cardiorespiratory support with veno-venous extracorporeal membrane oxygenation (VV-ECMO) for severe respiratory failure. This case highlights the potential for severe acquired immunodeficiency in this patient cohort and further postnatal surveillance is highly recommended.Pneumocystis jirovecii is recognized as an opportunistic pathogen in immunosuppressed patients. We report a case of severe Pneumocystis pneumonia (PCP) in an infant with acquired combined immunodeficiency secondary to maternal chemotherapy exposure during the second and third trimesters of pregnancy. The infant required cardiorespiratory support with veno-venous extracorporeal membrane oxygenation (VV-ECMO) for severe respiratory failure. This case highlights the potential for severe acquired immunodeficiency in this patient cohort and further postnatal surveillance is highly recommended.
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    Journal Title
    Case Reports in Pediatrics
    Volume
    2020
    DOI
    https://doi.org/10.1155/2020/5740304
    Copyright Statement
    © 2020 Adeline Yi Ling Lim et al. This is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Biomedical and clinical sciences
    Science & Technology
    Life Sciences & Biomedicine
    Pediatrics
    RESPIRATORY-DISTRESS-SYNDROME
    CARINII
    Publication URI
    http://hdl.handle.net/10072/396116
    Collection
    • Journal articles

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