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dc.contributor.authorTobin, Barbara
dc.contributor.authorCostalat, Guillaume
dc.contributor.authorRenshaw, Gillian MC
dc.date.accessioned2020-08-06T06:12:52Z
dc.date.available2020-08-06T06:12:52Z
dc.date.issued2020
dc.identifier.issn1439-6319
dc.identifier.doi10.1007/s00421-020-04310-y
dc.identifier.urihttp://hdl.handle.net/10072/396267
dc.description.abstractPurpose: The purpose of this single-blind, repeated measures study was to investigate the effect of two hypoxic patterns, continuous or intermittent on key markers of haematological adaptation, stress and cardiac damage in healthy senior participants. Methods: Fifteen healthy senior participants each followed a three-phase protocol over 3 consecutive weeks: (1) 5 consecutive days of breathing room air without a mask (2) 5 days of normoxic mask breathing (sham, FiO2 = 21%) (3) 5 days of intermittent hypoxia (IH) tailored to achieve a mean peripheral oxygen saturation (SpO2) of 85% during ~ 70 min of cumulative exposure to hypoxia. After a 5-month washout period, participants were recalled to undertake continuous hypoxia (CH, SpO2 = 85%, ~ 70 min). The red blood cell count (RBCc), haemoglobin concentration ([Hb]), haematocrit (Hct), percentage of reticulocytes (% Retics), secretory immunoglobulin A (S-IgA), cortisol, cardiac troponin T (cTnT) and the OFF-score (i.e. [Hb]∙10-60∙%Retics) were measured. Results: RBCc only increased by day 5 of IH treatment compared to day 5 baseline values (+ 7.7%, p < 0.01) and day 5 Sham values (+ 12.9%, p < 0.01). [Hb] only increased by day 5 of IH treatment compared to day 5 baseline values (+ 14.7%, p < 0.01) and day 5 Sham values (+ 14.3%, p < 0.01). Hct (+ 12.7%, p < 0.01) and the OFF-score (p < 0.05) increased only during the final day of IH treatment. No difference was observed in S-IgA, cortisol or cTnT following IH or CH. Conclusion: These results revealed that inherent differences in the IH and CH hypoxic patterns could provide crucial components required to trigger hematological changes in senior individuals, without eliciting immunological stress responses or damaging the myocardium.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofpagefrom707
dc.relation.ispartofpageto718
dc.relation.ispartofissue3
dc.relation.ispartofjournalEuropean Journal of Applied Physiology
dc.relation.ispartofvolume120
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchcode4207
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsPhysiology
dc.subject.keywordsHypoxic pattern
dc.titleIntermittent not continuous hypoxia provoked haematological adaptations in healthy seniors: hypoxic pattern may hold the key
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationTobin, B; Costalat, G; Renshaw, GMC, Intermittent not continuous hypoxia provoked haematological adaptations in healthy seniors: hypoxic pattern may hold the key, European Journal of Applied Physiology , 2020, 120 (3), pp. 707-718
dcterms.dateAccepted2020-01-27
dc.date.updated2020-08-06T06:11:45Z
gro.hasfulltextNo Full Text
gro.griffith.authorRenshaw, Gillian M.
gro.griffith.authorTobin, Barbara M.


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