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  • The clinical profile of NMOSD in Australia and New Zealand

    Author(s)
    Bukhari, Wajih
    Clarke, Laura
    O'Gorman, Cullen
    Khalilidehkordi, Elham
    Arnett, Simon
    Prain, Kerri M
    Woodhall, Mark
    Silvestrini, Roger
    Bundell, Christine S
    Ramanathan, Sudarshini
    Abernethy, David
    Bhuta, Sandeep
    Blum, Stefan
    Boggild, Mike
    Boundy, Karyn
    Brew, Bruce J
    Brownlee, Wallace
    Butzkueven, Helmut
    Carroll, William M
    Chen, Celia
    Coulthard, Alan
    Dale, Russell C
    Das, Chandi
    Dear, Keith
    Fabis-Pedrini, Marzena J
    Fulcher, David
    Gillis, David
    Hawke, Simon
    Heard, Robert
    Henderson, Andrew PD
    Heshmat, Saman
    Hodgkinson, Suzanne
    Jimenez-Sanchez, Sofia
    Kilpatrick, Trevor J
    King, John
    Kneebone, Chris
    Kornberg, Andrew J
    Lechner-Scott, Jeannette
    Lin, Ming-Wei
    Lynch, Christopher
    Macdonnell, Richard AL
    Mason, Deborah F
    McCombe, Pamela A
    Pereira, Jennifer
    Pollard, John D
    Reddel, Stephen W
    Shaw, Cameron
    Spies, Judith
    Stankovich, James
    Sutton, Ian
    Vucic, Steve
    Walsh, Michael
    Wong, Richard C
    Yiu, Eppie M
    Barnett, Michael H
    Kermode, Allan G
    Marriott, Mark P
    Parratt, John
    Slee, Mark
    Taylor, Bruce V
    Willoughby, Ernest
    Wilson, Robert J
    Brilot, Fabienne
    Vincent, Angela
    Waters, Patrick
    Broadley, Simon A
    Griffith University Author(s)
    Broadley, Simon
    Bhuta, Sandeep
    Khalilidehkordi, Ellie
    Arnett, Simon
    Clarke, Laura
    Bukhari, Wajih u.
    O'Gorman, Cullen
    Heshmat, Sam
    Jimenez Sanchez, Sofia
    Year published
    2020
    Metadata
    Show full item record
    Abstract
    Neuromyelitis optica spectrum disorders (NMOSD) are an inflammation of the central nervous system associated with autoantibodies to aquaporin-4. We have undertaken a clinic-based survey of NMOSD in the Australia and New Zealand populations with the aim of characterising the clinical features and establishing the value of recently revised diagnostic criteria. Cases of possible NMOSD and age and sex-matched controls with multiple sclerosis (MS) were referred from centres across Australia and New Zealand. Cases were classified as NMOSD if they met the 2015 IPND criteria and remained as suspected NMOSD if they did not. Clinical ...
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    Neuromyelitis optica spectrum disorders (NMOSD) are an inflammation of the central nervous system associated with autoantibodies to aquaporin-4. We have undertaken a clinic-based survey of NMOSD in the Australia and New Zealand populations with the aim of characterising the clinical features and establishing the value of recently revised diagnostic criteria. Cases of possible NMOSD and age and sex-matched controls with multiple sclerosis (MS) were referred from centres across Australia and New Zealand. Cases were classified as NMOSD if they met the 2015 IPND criteria and remained as suspected NMOSD if they did not. Clinical and paraclinical data were compared across the three groups. NMOSD was confirmed in 75 cases and 89 had suspected NMOSD. There were 101 controls with MS. Age at onset, relapse rates and EDSS scores were significantly higher in NMOSD than in MS. Lesions and symptoms referable to the optic nerve were more common in NMOSD whereas brainstem, cerebellar and cerebral lesions were more common in MS. Longitudinally extensive spinal cord lesions were seen in 48/71 (68%) of cases with NMOSD. Elevations of CSF, white cell count and protein were more common in NMOSD. We have confirmed a clinical pattern of NMOSD that has been seen in several geographical regions. We have demonstrated the clinical utility of the current diagnostic criteria. Distinct patterns of disease are evident in NMOSD and MS, but there remains a large number of patients with NMOSD-like features who do not meet the current diagnostic criteria for NMOSD and remain a diagnostic challenge.
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    Journal Title
    Journal of Neurology
    Volume
    267
    Issue
    5
    DOI
    https://doi.org/10.1007/s00415-020-09716-4
    Subject
    Clinical sciences
    Neurosciences
    Science & Technology
    Life Sciences & Biomedicine
    Clinical Neurology
    Neuromyelitis optica
    Neurology
    Publication URI
    http://hdl.handle.net/10072/396283
    Collection
    • Journal articles

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