Show simple item record

dc.contributor.authorXie, J
dc.contributor.authorBi, Y
dc.contributor.authorXu, S
dc.contributor.authorHan, Y
dc.contributor.authorIdris, A
dc.contributor.authorZhang, H
dc.contributor.authorLi, X
dc.contributor.authorBai, J
dc.contributor.authorZhang, Y
dc.contributor.authorFeng, R
dc.date.accessioned2020-08-09T23:49:57Z
dc.date.available2020-08-09T23:49:57Z
dc.date.issued2020
dc.identifier.issn0168-1702
dc.identifier.doi10.1016/j.virusres.2020.198105
dc.identifier.urihttp://hdl.handle.net/10072/396295
dc.description.abstractPseudorabies virus (PRV) is one of the most destructive swine pathogens and leads to huge economic losses to the global pig industry. Type I interferons (IFNs) plays a pivotal role in the innate immune response to virus infection via induction of a series of interferon-stimulated genes (ISGs) expression. IFN-induced transmembrane (IFITM) proteins, a group of ISGs, are important host self-restriction factors, possessing a broad spectrum of antiviral effects. They are known confer resistance to a variety of RNA and DNA viruses. However, little is known about the role of IFITMs in PRV infections. In this study, we show that IFITM is crucial for controlling PRV infection and that IFITM proteins can interfere with PRV cell binding and entry. Furthermore, we showed that IFITM2-mediated inhibition of PRV entry requires the cholesterol pathway. Collectively, these results provide insight into the anti-PRV role of IFITM proteins and this inhibition possible associated with the change of cholesterol in the endosome, further underlying the importance of cholesterol in virus infection.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom198105
dc.relation.ispartofjournalVirus Research
dc.relation.ispartofvolume287
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchAgricultural, veterinary and food sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode30
dc.subject.fieldofresearchcode32
dc.subject.keywordsIFITM proteins
dc.subject.keywordsPseudorabies virus
dc.subject.keywordscholesterol
dc.subject.keywordsendosomal
dc.titleHost antiviral protein IFITM2 restricts pseudorabies virus replication
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationXie, J; Bi, Y; Xu, S; Han, Y; Idris, A; Zhang, H; Li, X; Bai, J; Zhang, Y; Feng, R, Host antiviral protein IFITM2 restricts pseudorabies virus replication, Virus Research, 2020, 287, pp. 198105
dcterms.dateAccepted2020-07-25
dcterms.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2020-08-07T01:20:20Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2020 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorIdris, Adi


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record