dc.contributor.author | Xie, J | |
dc.contributor.author | Bi, Y | |
dc.contributor.author | Xu, S | |
dc.contributor.author | Han, Y | |
dc.contributor.author | Idris, A | |
dc.contributor.author | Zhang, H | |
dc.contributor.author | Li, X | |
dc.contributor.author | Bai, J | |
dc.contributor.author | Zhang, Y | |
dc.contributor.author | Feng, R | |
dc.date.accessioned | 2020-08-09T23:49:57Z | |
dc.date.available | 2020-08-09T23:49:57Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0168-1702 | |
dc.identifier.doi | 10.1016/j.virusres.2020.198105 | |
dc.identifier.uri | http://hdl.handle.net/10072/396295 | |
dc.description.abstract | Pseudorabies virus (PRV) is one of the most destructive swine pathogens and leads to huge economic losses to the global pig industry. Type I interferons (IFNs) plays a pivotal role in the innate immune response to virus infection via induction of a series of interferon-stimulated genes (ISGs) expression. IFN-induced transmembrane (IFITM) proteins, a group of ISGs, are important host self-restriction factors, possessing a broad spectrum of antiviral effects. They are known confer resistance to a variety of RNA and DNA viruses. However, little is known about the role of IFITMs in PRV infections. In this study, we show that IFITM is crucial for controlling PRV infection and that IFITM proteins can interfere with PRV cell binding and entry. Furthermore, we showed that IFITM2-mediated inhibition of PRV entry requires the cholesterol pathway. Collectively, these results provide insight into the anti-PRV role of IFITM proteins and this inhibition possible associated with the change of cholesterol in the endosome, further underlying the importance of cholesterol in virus infection. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofpagefrom | 198105 | |
dc.relation.ispartofjournal | Virus Research | |
dc.relation.ispartofvolume | 287 | |
dc.subject.fieldofresearch | Biological sciences | |
dc.subject.fieldofresearch | Agricultural, veterinary and food sciences | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearchcode | 31 | |
dc.subject.fieldofresearchcode | 30 | |
dc.subject.fieldofresearchcode | 32 | |
dc.subject.keywords | IFITM proteins | |
dc.subject.keywords | Pseudorabies virus | |
dc.subject.keywords | cholesterol | |
dc.subject.keywords | endosomal | |
dc.title | Host antiviral protein IFITM2 restricts pseudorabies virus replication | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Xie, J; Bi, Y; Xu, S; Han, Y; Idris, A; Zhang, H; Li, X; Bai, J; Zhang, Y; Feng, R, Host antiviral protein IFITM2 restricts pseudorabies virus replication, Virus Research, 2020, 287, pp. 198105 | |
dcterms.dateAccepted | 2020-07-25 | |
dcterms.license | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.date.updated | 2020-08-07T01:20:20Z | |
dc.description.version | Accepted Manuscript (AM) | |
gro.rights.copyright | © 2020 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Idris, Adi | |