PRES-like presentation in MOG antibody-related demyelination (MARD)

Corbett, Joel; Bhuta, Sandeep; Prain, Kerri; Brilot, Fabienne; Sabet, Arman; Broadley, Simon A

doi:10.1016/j.jocn.2020.01.034

Author(s)

Corbett, Joel

Bhuta, Sandeep

Prain, Kerri

Brilot, Fabienne

Sabet, Arman

Broadley, Simon A

Griffith University Author(s)

Broadley, Simon

Year published

2020

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Abstract

A 33-year-old male presented with a progressive four-week history of frontal headache and left visual field impairment. MRI brain confirmed bilateral, asymmetric, occipital vasogenic oedema, suggestive of posterior reversible encephalopathy syndrome (PRES). Serum testing for MOG antibodies was positive, confirming a diagnosis of MOG antibody-related demyelination (MARD). A similar PRES-like pattern of white matter inflammation has been reported previously in neuromyelitis optica spectrum disorder but has not previously been reported in MARD.A 33-year-old male presented with a progressive four-week history of frontal headache and left visual field impairment. MRI brain confirmed bilateral, asymmetric, occipital vasogenic oedema, suggestive of posterior reversible encephalopathy syndrome (PRES). Serum testing for MOG antibodies was positive, confirming a diagnosis of MOG antibody-related demyelination (MARD). A similar PRES-like pattern of white matter inflammation has been reported previously in neuromyelitis optica spectrum disorder but has not previously been reported in MARD.
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