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  • The effect of cannabidiol on simulated car driving performance: A randomised, double-blind, placebo-controlled, crossover, dose-ranging clinical trial protocol

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    Accepted Manuscript (AM)
    Author(s)
    McCartney, Danielle
    Benson, Melissa J
    Suraev, Anastasia S
    Irwin, Christopher
    Arkell, Thomas R
    Grunstein, Ronald R
    Hoyos, Camilla M
    McGregor, Iain S
    Griffith University Author(s)
    Irwin, Chris G.
    McCartney, Danielle J.
    Year published
    2020
    Metadata
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    Abstract
    Objective: Interest in the use of cannabidiol (CBD) is increasing worldwide as its therapeutic effects are established and legal restrictions moderated. Unlike Δ9-tetrahydrocannabinol (Δ9-THC), CBD does not appear to cause cognitive or psychomotor impairment. However, further assessment of its effects on cognitively demanding day-to-day activities, such as driving, is warranted. Here, we describe a study investigating the effects of CBD on simulated driving and cognitive performance. Methods: Thirty healthy individuals will be recruited to participate in this randomised, double-blind, placebo-controlled crossover trial. ...
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    Objective: Interest in the use of cannabidiol (CBD) is increasing worldwide as its therapeutic effects are established and legal restrictions moderated. Unlike Δ9-tetrahydrocannabinol (Δ9-THC), CBD does not appear to cause cognitive or psychomotor impairment. However, further assessment of its effects on cognitively demanding day-to-day activities, such as driving, is warranted. Here, we describe a study investigating the effects of CBD on simulated driving and cognitive performance. Methods: Thirty healthy individuals will be recruited to participate in this randomised, double-blind, placebo-controlled crossover trial. Participants will complete four research sessions each involving two 30-min simulated driving performance tests completed 45 and 210 min following oral ingestion of placebo or 15, 300, or 1,500 mg CBD. Cognitive function and subjective drug effects will be measured, and blood and oral fluid sampled, at regular intervals. Oral fluid drug testing will be performed using the Securetec DrugWipe® 5S and Dräger DrugTest® 5000 devices to determine whether CBD increases the risk of “false-positive” roadside tests to Δ9-THC. Noninferiority analyses will test the hypothesis that CBD is no more impairing than placebo. Conclusion: This study will clarify the risks involved in driving following CBD use and assist in ensuring the safe use of CBD by drivers.
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    Journal Title
    Human Psychopharmacology: Clinical and Experimental
    DOI
    https://doi.org/10.1002/hup.2749
    Copyright Statement
    © 2020 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: The effect of cannabidiol on simulated car driving performance: A randomised, double‐blind, placebo‐controlled, crossover, dose‐ranging clinical trial protocol, Human Psychopharmacology: Clinical and Experimental, Early View 2002, which has been published in final form at 10.1002/hup.2749. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
    Note
    This publication has been entered into Griffith Research Online as an Advanced Online Version.
    Subject
    Pharmacology and pharmaceutical sciences
    Psychology
    Cognitive and computational psychology
    cannabidiol
    cognition
    driving simulation
    medicinal cannabis
    mobile drug testing
    Publication URI
    http://hdl.handle.net/10072/396338
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    • Journal articles

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