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dc.contributor.authorMcCartney, Danielle
dc.contributor.authorBenson, Melissa J
dc.contributor.authorSuraev, Anastasia S
dc.contributor.authorIrwin, Christopher
dc.contributor.authorArkell, Thomas R
dc.contributor.authorGrunstein, Ronald R
dc.contributor.authorHoyos, Camilla M
dc.contributor.authorMcGregor, Iain S
dc.date.accessioned2020-08-09T22:53:15Z
dc.date.available2020-08-09T22:53:15Z
dc.date.issued2020
dc.identifier.issn0885-6222
dc.identifier.doi10.1002/hup.2749
dc.identifier.urihttp://hdl.handle.net/10072/396338
dc.description.abstractObjective: Interest in the use of cannabidiol (CBD) is increasing worldwide as its therapeutic effects are established and legal restrictions moderated. Unlike Δ9-tetrahydrocannabinol (Δ9-THC), CBD does not appear to cause cognitive or psychomotor impairment. However, further assessment of its effects on cognitively demanding day-to-day activities, such as driving, is warranted. Here, we describe a study investigating the effects of CBD on simulated driving and cognitive performance. Methods: Thirty healthy individuals will be recruited to participate in this randomised, double-blind, placebo-controlled crossover trial. Participants will complete four research sessions each involving two 30-min simulated driving performance tests completed 45 and 210 min following oral ingestion of placebo or 15, 300, or 1,500 mg CBD. Cognitive function and subjective drug effects will be measured, and blood and oral fluid sampled, at regular intervals. Oral fluid drug testing will be performed using the Securetec DrugWipe® 5S and Dräger DrugTest® 5000 devices to determine whether CBD increases the risk of “false-positive” roadside tests to Δ9-THC. Noninferiority analyses will test the hypothesis that CBD is no more impairing than placebo. Conclusion: This study will clarify the risks involved in driving following CBD use and assist in ensuring the safe use of CBD by drivers.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherWiley
dc.relation.ispartofjournalHuman Psychopharmacology: Clinical and Experimental
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode1115
dc.subject.fieldofresearchcode1702
dc.subject.fieldofresearchcode1701
dc.subject.keywordscannabidiol
dc.subject.keywordscognition
dc.subject.keywordsdriving simulation
dc.subject.keywordsmedicinal cannabis
dc.subject.keywordsmobile drug testing
dc.titleThe effect of cannabidiol on simulated car driving performance: A randomised, double-blind, placebo-controlled, crossover, dose-ranging clinical trial protocol
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMcCartney, D; Benson, MJ; Suraev, AS; Irwin, C; Arkell, TR; Grunstein, RR; Hoyos, CM; McGregor, IS, The effect of cannabidiol on simulated car driving performance: A randomised, double-blind, placebo-controlled, crossover, dose-ranging clinical trial protocol, Human Psychopharmacology: Clinical and Experimental, 2020
dcterms.dateAccepted2020-05-28
dc.date.updated2020-08-07T04:26:49Z
dc.description.versionPost-print
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.rights.copyright© 2020 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: The effect of cannabidiol on simulated car driving performance: A randomised, double‐blind, placebo‐controlled, crossover, dose‐ranging clinical trial protocol, Human Psychopharmacology: Clinical and Experimental, Early View 2002, which has been published in final form at 10.1002/hup.2749. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
gro.hasfulltextFull Text
gro.griffith.authorIrwin, Chris G.


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