Induced pluripotent stem cell line (LCSBi001-A) derived from a patient with Parkinson's disease carrying the p.D620N mutation in VPS35

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Author(s)
Larsen, Simone B
Hanss, Zoe
Cruciani, Gerald
Massart, Francois
Barbuti, Peter A
Mellick, George
Kruger, Rejko
Griffith University Author(s)
Year published
2020
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Abstract
Fibroblasts were obtained from a 76 year-old man diagnosed with Parkinson's disease (PD). The disease is caused by a heterozygous p.D620N mutation in VPS35. Induced pluripotent stem cells (iPSCs) were generated using the CytoTune™-iPS 2.0 Sendai Reprogramming Kit (Thermo Fisher Scientific). The presence of the c.1858G > A base exchange in exon 15 of VPS35 was confirmed by Sanger sequencing. The iPSCs are free of genomically integrated reprogramming genes, express pluripotency markers, display in vitro differentiation potential to the three germ layers and have karyotypic integrity. Our iPSC line will be useful for studying ...
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Journal Title
Stem Cell Research
Volume
45
DOI
Funder(s)
NHMRC
Grant identifier(s)
GNT1084560
Copyright Statement
© 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
Subject
Biological sciences
Biomedical and clinical sciences
Genetics
Medical biotechnology
Oncology and carcinogenesis
Science & Technology
Life Sciences & Biomedicine
Cell & Tissue Engineering
Biotechnology & Applied Microbiology
Cell Biology
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