The impact of obesity on the gestational diabetes differential between pregnant women with and without polycystic ovary syndrome

Abstract

Bahri Khomami et al1 recently published a meta‐analysis investigating the role of maternal obesity on the association between polycystic ovary syndrome (PCOS) and fetal and maternal outcomes. One of the outcomes was gestational diabetes mellitus (GDM), and they included 39 studies that recruited a total of 11 565 women with PCOS and 177 296 women without PCOS and compared them to assess the role of PCOS per se on the development of GDM. The fundamental question that the authors attempted to answer was if there was a higher risk for women with PCOS in terms of GDM and if this was independent of other GDM risk factors. The authors used univariate meta‐regression as well as subgroup analysis of BMI matched and non‐matched studies to conclude that indeed there was an independent predictive role of PCOS on the development of GDM.1