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dc.contributor.authorWilliams, Tracy Ann
dc.contributor.authorGomez-Sanchez, Celso E
dc.contributor.authorRainey, William E
dc.contributor.authorGiordano, Thomas J
dc.contributor.authorLam, Alfred K
dc.contributor.authorMarker, Alison
dc.contributor.authorMete, Ozgur
dc.contributor.authorYamazaki, Yuto
dc.contributor.authorZerbini, Maria Claudia Nogueira
dc.contributor.authorBeuschlein, Felix
dc.contributor.authorSatoh, Fumitoshi
dc.contributor.authorBurrello, Jacopo
dc.contributor.authorSchneider, Holger
dc.contributor.authorLenders, Jacques WM
dc.contributor.authoret al.
dc.date.accessioned2020-08-11T01:46:30Z
dc.date.available2020-08-11T01:46:30Z
dc.date.issued2020
dc.identifier.issn1945-7197
dc.identifier.doi10.1210/clinem/dgaa484
dc.identifier.urihttp://hdl.handle.net/10072/396399
dc.description.abstractOBJECTIVE: Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA). CONTEXT: Unilateral PA is the most common surgically-treated form of hypertension. Morphologic examination combined with CYP11B2 (aldosterone synthase) immunostaining reveals diverse histopathologic features of lesions in the resected adrenals. PATIENTS AND METHODS: Surgically removed adrenals (n= 37) from 90 patients operated from 2015 to 2018 in Munich, Germany, were selected to represent the broad histologic spectrum of unilateral PA. Five pathologists (Group 1 from Germany, Italy and Japan) evaluated the histopathology of haematoxylin-eosin and CYP11B2 immunostained sections and a consensus was established to define the identifiable features. The consensus was subsequently used by six additional pathologists (Group 2 from Australia, Brazil, Canada, Japan, UK, USA) for the assessment of all adrenals with disagreement for histopathologic diagnoses among group 1 pathologists. RESULTS: Consensus was achieved to define histopathologic features associated with PA. Use of CYP11B2 immunostaining resulted in a change of the original haematoxylin-eosin morphology-driven diagnosis in 5 (14%) of 37 cases. Using the consensus criteria, group 2 pathologists agreed for the evaluation of 11 of the 12 cases of disagreement among group 1 pathologists. CONCLUSION: The HISTALDO (histopathology of primary aldosteronism) consensus is useful to standardize nomenclature and achieve consistency among pathologists for the histopathologic diagnosis of unilateral PA. CYP11B2 immunohistochemistry should be incorporated into the routine clinical diagnostic workup to localize the likely source of aldosterone production.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofjournalThe Journal of Clinical Endocrinology & Metabolism
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.subject.keywordsCYP11B2
dc.subject.keywordsPrimary aldosteronism
dc.subject.keywordsadrenal gland
dc.subject.keywordsdiagnostic histopathology
dc.subject.keywordsimmunohistochemistry
dc.titleInternational histopathology consensus for unilateral primary aldosteronism
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationWilliams, TA; Gomez-Sanchez, CE; Rainey, WE; Giordano, TJ; Lam, AK; Marker, A; Mete, O; Yamazaki, Y; Zerbini, MCN; Beuschlein, F; Satoh, F; Burrello, J; Schneider, H; Lenders, JWM; et al., International histopathology consensus for unilateral primary aldosteronism, The Journal of Clinical Endocrinology & Metabolism, 2020
dc.date.updated2020-08-11T01:30:51Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2020 Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in the Journal of Clinical Endocrinology and Metabolism following peer review. The definitive publisher-authenticated version International histopathology consensus for unilateral primary aldosteronism, Journal of Clinical Endocrinology and Metabolism, 2020 is available online at: https://doi.org/10.1210/clinem/dgaa484.
gro.hasfulltextFull Text
gro.griffith.authorLam, Alfred K.


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