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dc.contributor.authorHofmann, Andreas
dc.contributor.authorWang, Conan
dc.contributor.authorTaylor, Paul
dc.contributor.authorCampbell, BE
dc.contributor.authorBoag, P.
dc.contributor.authorCantacessi, C
dc.contributor.authorHu, M.
dc.contributor.authorSindhu, Z.
dc.contributor.authorLoukas, A.
dc.contributor.authorSternberg, PW
dc.contributor.authorGasser, RB
dc.date.accessioned2017-05-03T15:18:58Z
dc.date.available2017-05-03T15:18:58Z
dc.date.issued2011
dc.date.modified2011-08-02T08:25:34Z
dc.identifier.urihttp://hdl.handle.net/10072/39644
dc.description.abstractAlmost nothing is known about atypical kinases in multicellular organisms, including parasites. We have analysed three RIO kinase genes, riok-1, riok-2 and riok-3, and their products from Haemonchus contortus, one of the most important parasitic nematodes of small ruminants. Based on comparative modelling using the known structures of RIOK-1 and RIOK-2 from Archaeoglobus fulgidus [1,2], the structural comparison of the three RIOKs shows that the RIOK domain harbouring the catalytic site is a wellconserved fold among parasitic nematodes, in particular between H. contortus and T. vitrinus. In a first attempt to probe the active site of RIOKs, with a view toward drug discovery, we conducted an in silico screen with the program LIDAEUS using the homology model of Hc-RIOK-1 and employing the SPECS database. Our findings indicate opportunities for the design of a novel class of nematodespecific inhibitors of RIO kinases. The latter aspect is of paramount importance, given the serious problems linked to anthelmintic resistance in parasitic nematode populations of livestock.
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherCurran Associates
dc.publisher.placeAustralia
dc.publisher.urihttp://www.lorneproteins.org/
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofconferencename36th Lorne Conference on Protein Structure and Function
dc.relation.ispartofconferencetitle36th Lorne Conference on Protein Structure and Function 2011. Proceedings
dc.relation.ispartofdatefrom2011-02-06
dc.relation.ispartofdateto2011-02-10
dc.relation.ispartoflocationLorne, Australia
dc.rights.retentionY
dc.subject.fieldofresearchStructural Biology (incl. Macromolecular Modelling)
dc.subject.fieldofresearchcode060112
dc.titleComparative modelling and virtual screening of atypical (RIO) protein kinases from Haemonchus contortus - promise as new targets for nematocidal drugs
dc.typeConference output
dc.type.descriptionE3 - Conferences (Extract Paper)
dc.type.codeE - Conference Publications
gro.facultyGriffith Sciences, School of Natural Sciences
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorHofmann, Andreas
gro.griffith.authorWang, Conan K.


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