dc.contributor.author | Hofmann, Andreas | |
dc.contributor.author | Wang, Conan | |
dc.contributor.author | Taylor, Paul | |
dc.contributor.author | Campbell, BE | |
dc.contributor.author | Boag, P. | |
dc.contributor.author | Cantacessi, C | |
dc.contributor.author | Hu, M. | |
dc.contributor.author | Sindhu, Z. | |
dc.contributor.author | Loukas, A. | |
dc.contributor.author | Sternberg, PW | |
dc.contributor.author | Gasser, RB | |
dc.date.accessioned | 2017-05-03T15:18:58Z | |
dc.date.available | 2017-05-03T15:18:58Z | |
dc.date.issued | 2011 | |
dc.date.modified | 2011-08-02T08:25:34Z | |
dc.identifier.uri | http://hdl.handle.net/10072/39644 | |
dc.description.abstract | Almost nothing is known about atypical kinases in multicellular organisms, including parasites. We have analysed three RIO kinase genes, riok-1, riok-2 and riok-3, and their products from Haemonchus contortus, one of the most important parasitic nematodes of small ruminants. Based on comparative modelling using the known structures of RIOK-1 and RIOK-2 from Archaeoglobus fulgidus [1,2], the structural comparison of the three RIOKs shows that the RIOK domain harbouring the catalytic site is a wellconserved fold among parasitic nematodes, in particular between H. contortus and T. vitrinus. In a first attempt to probe the active site of RIOKs, with a view toward drug discovery, we conducted an in silico screen with the program LIDAEUS using the homology model of Hc-RIOK-1 and employing the SPECS database. Our findings indicate opportunities for the design of a novel class of nematodespecific inhibitors of RIO kinases. The latter aspect is of paramount importance, given the serious problems linked to anthelmintic resistance in parasitic nematode populations of livestock. | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Curran Associates | |
dc.publisher.place | Australia | |
dc.publisher.uri | http://www.lorneproteins.org/ | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofconferencename | 36th Lorne Conference on Protein Structure and Function | |
dc.relation.ispartofconferencetitle | 36th Lorne Conference on Protein Structure and Function 2011. Proceedings | |
dc.relation.ispartofdatefrom | 2011-02-06 | |
dc.relation.ispartofdateto | 2011-02-10 | |
dc.relation.ispartoflocation | Lorne, Australia | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Structural Biology (incl. Macromolecular Modelling) | |
dc.subject.fieldofresearchcode | 060112 | |
dc.title | Comparative modelling and virtual screening of atypical (RIO) protein kinases from Haemonchus contortus - promise as new targets for nematocidal drugs | |
dc.type | Conference output | |
dc.type.description | E3 - Conferences (Extract Paper) | |
dc.type.code | E - Conference Publications | |
gro.faculty | Griffith Sciences, School of Natural Sciences | |
gro.date.issued | 2011 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Hofmann, Andreas | |
gro.griffith.author | Wang, Conan K. | |