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dc.contributor.authorMoradali, M Fata
dc.contributor.authorRehm, Bernd HA
dc.date.accessioned2020-08-12T04:32:40Z
dc.date.available2020-08-12T04:32:40Z
dc.date.issued2020
dc.identifier.issn1740-1526
dc.identifier.doi10.1038/s41579-019-0313-3
dc.identifier.urihttp://hdl.handle.net/10072/396455
dc.description.abstractBacteria are prime cell factories that can efficiently convert carbon and nitrogen sources into a large diversity of intracellular and extracellular biopolymers, such as polysaccharides, polyamides, polyesters, polyphosphates, extracellular DNA and proteinaceous components. Bacterial polymers have important roles in pathogenicity, and their varied chemical and material properties make them suitable for medical and industrial applications. The same biopolymers when produced by pathogenic bacteria function as major virulence factors, whereas when they are produced by non-pathogenic bacteria, they become food ingredients or biomaterials. Interdisciplinary research has shed light on the molecular mechanisms of bacterial polymer synthesis, identified new targets for antibacterial drugs and informed synthetic biology approaches to design and manufacture innovative materials. This Review summarizes the role of bacterial polymers in pathogenesis, their synthesis and their material properties as well as approaches to design cell factories for production of tailor-made bio-based materials suitable for high-value applications.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherNature Publishing Group
dc.relation.ispartofpagefrom195
dc.relation.ispartofpageto210
dc.relation.ispartofissue4
dc.relation.ispartofjournalNature Reviews Microbiology
dc.relation.ispartofvolume18
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchMedical Microbiology
dc.subject.fieldofresearchcode0605
dc.subject.fieldofresearchcode1108
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsPSEUDOMONAS-AERUGINOSA BIOFILM
dc.subject.keywordsSYNTHETIC BIOLOGY
dc.titleBacterial biopolymers: from pathogenesis to advanced materials
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMoradali, MF; Rehm, BHA, Bacterial biopolymers: from pathogenesis to advanced materials, Nature Reviews Microbiology , 2020, 18 (4)
dcterms.dateAccepted2019-12-05
dc.date.updated2020-08-12T04:31:19Z
gro.hasfulltextNo Full Text
gro.griffith.authorRehm, Bernd


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