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dc.contributor.authorPandey, Manisha
dc.contributor.authorGood, Michael F
dc.date.accessioned2020-08-12T05:08:00Z
dc.date.available2020-08-12T05:08:00Z
dc.date.issued2020
dc.identifier.issn1940-6029
dc.identifier.doi10.1007/978-1-0716-0467-0_22
dc.identifier.urihttp://hdl.handle.net/10072/396461
dc.description.abstractSkin infections caused by Streptococcus pyogenes are a significant health concern in the tropics and among Indigenous populations of developed countries. To study the immunobiology of skin infections and to develop preventative and therapeutic measures to target these infections, an in vivo model is vital. We developed a mouse model to investigate immunity to skin infections and for testing the efficacy of several vaccine candidates. This article describes the method of induction of superficial skin infections, their progression and regression, and processing of samples to obtain critical readouts and analyses. This model could be valuable to inform clinical studies.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer US
dc.relation.ispartofpagefrom287
dc.relation.ispartofpageto301
dc.relation.ispartofjournalMethods in Molecular Biology
dc.relation.ispartofvolume2136
dc.subject.fieldofresearchOther chemical sciences
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchcode3499
dc.subject.fieldofresearchcode3101
dc.subject.keywordsBacterial burden
dc.subject.keywordsPyoderma
dc.subject.keywordsScarification
dc.subject.keywordsStreptococcus pyogenes
dc.subject.keywordsSuperficial skin infection
dc.titleA Superficial Skin Scarification Method in Mice to Mimic Streptococcus pyogenes Skin Infection in Humans
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationPandey, M; Good, MF, A Superficial Skin Scarification Method in Mice to Mimic Streptococcus pyogenes Skin Infection in Humans, Methods in Molecular Biology, 2020, 2136, pp. 287-301
dc.date.updated2020-08-12T05:06:50Z
gro.hasfulltextNo Full Text
gro.griffith.authorGood, Michael F.
gro.griffith.authorPandey, Manisha


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