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dc.contributor.authorVijay, Rahul
dc.contributor.authorGuthmiller, Jenna J
dc.contributor.authorSturtz, Alexandria J
dc.contributor.authorSurette, Fionna A
dc.contributor.authorRogers, Kai J
dc.contributor.authorSompallae, Ramakrishna R
dc.contributor.authorLi, Fengyin
dc.contributor.authorPope, Rosemary L
dc.contributor.authorChan, Jo-Anne
dc.contributor.authorRivera, Fabian de Labastida
dc.contributor.authorAndrew, Dean
dc.contributor.authorWebb, Lachlan
dc.contributor.authorEngwerda, Christian R
dc.contributor.authorBoyle, Michelle J
dc.contributor.authoret al.
dc.date.accessioned2020-08-18T05:39:51Z
dc.date.available2020-08-18T05:39:51Z
dc.date.issued2020
dc.identifier.issn1529-2908
dc.identifier.doi10.1038/s41590-020-0678-5
dc.identifier.urihttp://hdl.handle.net/10072/396527
dc.description.abstractPlasmodium parasite-specific antibodies are critical for protection against malaria, yet the development of long-lived and effective humoral immunity against Plasmodium takes many years and multiple rounds of infection and cure. Here, we report that the rapid development of short-lived plasmablasts during experimental malaria unexpectedly hindered parasite control by impeding germinal center responses. Metabolic hyperactivity of plasmablasts resulted in nutrient deprivation of the germinal center reaction, limiting the generation of memory B cell and long-lived plasma cell responses. Therapeutic administration of a single amino acid to experimentally infected mice was sufficient to overcome the metabolic constraints imposed by plasmablasts and enhanced parasite clearance and the formation of protective humoral immune memory responses. Thus, our studies not only challenge the current model describing the role and function of blood-stage Plasmodium-induced plasmablasts but they also reveal new targets and strategies to improve anti-Plasmodium humoral immunity.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofpagefrom790
dc.relation.ispartofpageto801
dc.relation.ispartofissue7
dc.relation.ispartofjournalNature Immunology
dc.relation.ispartofvolume21
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode3204
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsMEMORY B-CELLS
dc.subject.keywordsBLOOD-STAGE MALARIA
dc.titleInfection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationVijay, R; Guthmiller, JJ; Sturtz, AJ; Surette, FA; Rogers, KJ; Sompallae, RR; Li, F; Pope, RL; Chan, J-A; Rivera, FDL; Andrew, D; Webb, L; Engwerda, CR; McCarthy, JS; Boyle, MJ; et al, Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria, Nature Immunology, 2020, 21 (7), pp. 790-801
dcterms.dateAccepted2020-04-01
dc.date.updated2020-08-18T00:32:01Z
gro.hasfulltextNo Full Text
gro.griffith.authorEngwerda, Christian R.
gro.griffith.authorBoyle, Michelle


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