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dc.contributor.authorHolden, S
dc.contributor.authorMaksoud, R
dc.contributor.authorEaton-Fitch, N
dc.contributor.authorCabanas, H
dc.contributor.authorStaines, D
dc.contributor.authorMarshall-Gradisnik, S
dc.date.accessioned2020-08-19T04:15:50Z
dc.date.available2020-08-19T04:15:50Z
dc.date.issued2020
dc.identifier.issn1479-5876
dc.identifier.doi10.1186/s12967-020-02452-3
dc.identifier.urihttp://hdl.handle.net/10072/396560
dc.description.abstractBACKGROUND: Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) or Systemic Exertion Intolerance Disease (SEID) present with a constellation of symptoms including debilitating fatigue that is unrelieved by rest. The pathomechanisms underlying this illness are not fully understood and the search for a biomarker continues, mitochondrial aberrations have been suggested as a possible candidate. The aim of this systematic review is to collate and appraise current literature on mitochondrial changes in ME/CFS/SEID patients compared to healthy controls. METHODS: Embase, PubMed, Scopus and Medline (EBSCO host) were systematically searched for articles assessing mitochondrial changes in ME/CFS/SEID patients compared to healthy controls published between January 1995 and February 2020. The list of articles was further refined using specific inclusion and exclusion criteria. Quality and bias were measured using the Joanna Briggs Institute Critical Appraisal Checklist for Case Control Studies. RESULTS: Nineteen studies were included in this review. The included studies investigated mitochondrial structural and functional differences in ME/CFS/SEID patients compared with healthy controls. Outcomes addressed by the papers include changes in mitochondrial structure, deoxyribonucleic acid/ribonucleic acid, respiratory function, metabolites, and coenzymes. CONCLUSION: Based on the included articles in the review it is difficult to establish the role of mitochondria in the pathomechanisms of ME/CFS/SEID due to inconsistencies across the studies. Future well-designed studies using the same ME/CFS/SEID diagnostic criteria and analysis methods are required to determine possible mitochondrial involvement in the pathomechanisms of ME/CFS/SEID.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofpagefrom290
dc.relation.ispartofissue1
dc.relation.ispartofjournalJournal of translational medicine
dc.relation.ispartofvolume18
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchHealth sciences
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode42
dc.subject.keywordsChronic Fatigue Syndrome
dc.subject.keywordsEnergy metabolism
dc.subject.keywordsMitochondria
dc.subject.keywordsMyalgic Encephalomyelitis
dc.subject.keywordsSystemic Exertion Intolerance Disease
dc.titleA systematic review of mitochondrial abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome/systemic exertion intolerance disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationHolden, S; Maksoud, R; Eaton-Fitch, N; Cabanas, H; Staines, D; Marshall-Gradisnik, S, A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome/systemic exertion intolerance disease, Journal of translational medicine, 2020, 18 (1), pp. 290
dcterms.dateAccepted2020-07-21
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-08-19T04:09:17Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativeco mmons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/ zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
gro.hasfulltextFull Text
gro.griffith.authorMarshall-Gradisnik, Sonya M.
gro.griffith.authorEaton-Fitch, Natalie R.
gro.griffith.authorStaines, Donald R.


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