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  • Epidemiology, treatment and outcome of patients with lower respiratory tract infection presenting to emergency departments with dyspnoea (AANZDEMandEuroDEMstudies)

    Author(s)
    Rousseau, Geoffroy
    Keijzers, Gerben
    van Meer, Oene
    Craig, Simon
    Karamercan, Mehmet
    Klim, Sharon
    Body, Richard
    Kuan, Win Sen
    Harjola, Veli-Pekka
    Jones, Peter
    Verschuren, Franck
    Holdgate, Anna
    Christ, Michael
    Golea, Adela
    et al.
    Griffith University Author(s)
    Keijzers, Gerben
    Year published
    2020
    Metadata
    Show full item record
    Abstract
    Objective: Lower respiratory tract infection (LRTI) is a frequent cause of dyspnoea in EDs, and is associated with considerable morbidity and mortality. We described and compared the management of this disease in Europe and Oceania/South-East Asia (SEA) cohorts. Methods: We conducted a prospective cohort study with three time points in Europe and Oceania/SEA. We included in this manuscript patients presenting to EDs with dyspnoea and a diagnosis of LRTI in ED. We collected comorbidities, chronic medication, clinical signs at arrival, laboratory parameters, ED management and patient outcomes. Results: A total of 1389 patients ...
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    Objective: Lower respiratory tract infection (LRTI) is a frequent cause of dyspnoea in EDs, and is associated with considerable morbidity and mortality. We described and compared the management of this disease in Europe and Oceania/South-East Asia (SEA) cohorts. Methods: We conducted a prospective cohort study with three time points in Europe and Oceania/SEA. We included in this manuscript patients presenting to EDs with dyspnoea and a diagnosis of LRTI in ED. We collected comorbidities, chronic medication, clinical signs at arrival, laboratory parameters, ED management and patient outcomes. Results: A total of 1389 patients were included, 773 in Europe and 616 in SEA. The European cohort had more comorbidities including chronic heart failure, obesity, chronic obstructive pulmonary disease and smoking. Levels of inflammatory markers were higher in Europe. There were more patients with inflammatory markers in Europe and more hypercapnia in Oceania/SEA. The use of antibiotics was higher in SEA (72.2% vs 61.8%, P < 0.001) whereas intravenous diuretics, non-invasive and invasive ventilation were higher in Europe. Intensive care unit admission rate was 9.9% in Europe cohort and 3.4% in Oceania/SEA cohort. ED mortality was 1% and overall in-hospital mortality was 8.7% with no differences between regions. Conclusions: More patients with LRTI in Europe presented with cardio-respiratory comorbidities, they received more adjunct therapies and had a higher intensive care unit admission rate than patients from Oceania/SEA, although mortality was similar between the two cohorts.
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    Journal Title
    Emergency Medicine Australasia
    DOI
    https://doi.org/10.1111/1742-6723.13567
    Note
    This publication has been entered in Griffith Research Online as an advanced online version.
    Subject
    Clinical sciences
    Health services and systems
    Public health
    Science & Technology
    Life Sciences & Biomedicine
    Emergency Medicine
    dyspnoea
    emergency
    Publication URI
    http://hdl.handle.net/10072/396605
    Collection
    • Journal articles

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