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dc.contributor.authorKavanaugh, A
dc.contributor.authorMarzo-Ortega, H
dc.contributor.authorVender, R
dc.contributor.authorWei, C-C
dc.contributor.authorBirt, J
dc.contributor.authorAdams, DH
dc.contributor.authorBenichou, O
dc.contributor.authorLin, C-Y
dc.contributor.authorNash, P
dc.date.accessioned2020-08-24T00:37:09Z
dc.date.available2020-08-24T00:37:09Z
dc.date.issued2019
dc.identifier.issn0392-856X
dc.identifier.urihttp://hdl.handle.net/10072/396665
dc.description.abstractObjectives: To report patient-reported outcomes (PROs) of ixekizumab-treated patients with psoriatic arthritis (PsA) and an inadequate response (IR) or intolerance to tumour necrosis factor inhibitors (TNFi) to 52 weeks. Methods: In SPIRIT-P2, patients with active PsA and an IR or intolerance to TNFi were randomised to ixekizumab 80 mg every 4 weeks (IXEQ4W; N=122) or every 2 weeks (IXEQ2W; N=123), or placebo (PBO; N=118) during the initial 24-week double-blind treatment period. At Week 16, background therapy was modified for IRs; additionally, IRs in the placebo group were re-randomised (1:1) to IXEQ2W or IXEQ4W. Patients receiving ixekizumab at Week 24 received the same dose during the study remainder. Patients completed several PROs for PsA disease activity, skin, health-related quality of life (HRQOL, and work through Week 52. Results: Ixekizumab-treated patients reported significant improvements versus PBO in 36-Item Short Form Health Survey version 2, European Quality of Life 5 Dimensions visual analogue scale, Bath Ankylosing Spondylitis Disease Activity Index (total score and question 2), and Work Productivity and Activity Impairment Questionnaire-Specific Health Problem (3 of 4 domains) through Week 24. At Week 24, 9% (PBO), 52% (IXEQ4W), and 50% (IXEQ2W) of patients reported Dermatology Life Quality Index scores of 0 or 1; 0% (PBO) and 24% (IXEQ4W and IXEQ2W) reported Itch Numeric Rating Scale score of 0. Where data were collected, improvements persisted through Week 52. Conclusions: In patients with PsA and an IR or intolerance to TNFi, ixekizumab significantly improved disease activity, skin symptoms, HRQOL, and work productivity to 52 weeks.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherClinical and Experimental Rheumatology
dc.publisher.urihttps://www.clinexprheumatol.org/abstract.asp?a=12947
dc.relation.ispartofpagefrom566
dc.relation.ispartofpageto574
dc.relation.ispartofissue4
dc.relation.ispartofjournalClinical and Experimental Rheumatology
dc.relation.ispartofvolume37
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsRheumatology
dc.subject.keywordsixekizumab
dc.subject.keywordsquality of life
dc.titleIxekizumab improves patient-reported outcomes in patients with active psoriatic arthritis and inadequate response to tumour necrosis factor inhibitors: SPIRIT-P2 results to 52 weeks
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationKavanaugh, A; Marzo-Ortega, H; Vender, R; Wei, C-C; Birt, J; Adams, DH; Benichou, O; Lin, C-Y; Nash, P, Ixekizumab improves patient-reported outcomes in patients with active psoriatic arthritis and inadequate response to tumour necrosis factor inhibitors: SPIRIT-P2 results to 52 weeks, Clinical and Experimental Rheumatology, 2019, 37 (4), pp. 566-574
dcterms.dateAccepted2018-08-27
dc.date.updated2020-08-24T00:34:19Z
gro.hasfulltextNo Full Text
gro.griffith.authorNash, Peter


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