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  • A 14-year retrospective analysis of indications and outcomes of autologous haemopoietic stem cell transplantation in regional Queensland: a single-centre experience

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    Accepted Manuscript (AM)
    Author(s)
    Hamilton, Elizabeth M
    Nath, Karthik D
    Vangaveti, Venkat N
    McCutchan, Andrew D
    Marsh, Jodie L
    Birchley, Andrew J
    Casey, John M
    McNamara, Caroline
    Lai, Hock C
    Morris, Edward S
    Hodges, Georgina
    Irving, Ian M
    Griffith University Author(s)
    Hamilton, Elizabeth M.
    Year published
    2020
    Metadata
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    Abstract
    Background: The Townsville Hospital is a tertiary hospital in North Queensland with one of the largest regional transplant centres in Australia, performing primarily autologous haemopoietic stem cell transplants (HSCT) for various haematological malignancies. Aims: This single-centre, retrospective, observational study aims to describe the activity and outcomes of autologous HSCT at The Townsville Hospital between 2003 and 2017 to verify safety standards. Methods: Patient-level data were collected, including demographics, frequency and indication for transplant, conditioning, current clinical status and cause of death. Key ...
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    Background: The Townsville Hospital is a tertiary hospital in North Queensland with one of the largest regional transplant centres in Australia, performing primarily autologous haemopoietic stem cell transplants (HSCT) for various haematological malignancies. Aims: This single-centre, retrospective, observational study aims to describe the activity and outcomes of autologous HSCT at The Townsville Hospital between 2003 and 2017 to verify safety standards. Methods: Patient-level data were collected, including demographics, frequency and indication for transplant, conditioning, current clinical status and cause of death. Key outcomes included overall survival, non-relapse mortality, incidence of therapy-related neoplasm and causes of death. Progression-free survival in the multiple myeloma (MM) subgroup was also assessed. Results: There were 319 autologous HSCT in 286 patients, with a median age of 58 years (range 14–71 years); 62% of patients were male. Indications for transplantation were: MM 53.7%, non-Hodgkin lymphoma 29.4%, Hodgkin lymphoma 5.0% and other 11.9%. Causes of death were: disease progression/relapse (65.2%), second malignancy (17.0%), infection (9.8%) and other (8.0%). Non-relapse mortality was 1.2% (95% confidence interval 0.4–3.0) and 3.2% (1.7–5.7) at 100 days and 1 year, respectively, post-HSCT. Overall survival at 2 years was 81.0% (73.8–86.4) for MM and 69.6% (58.8–78.1) for non-Hodgkin lymphoma. The median progression-free survival in the MM cohort was 3.3 years. Conclusion: The Townsville Hospital transplant centre provides an important transplant service in regional Queensland, with outcomes comparable to national data. We reported a relatively high rate of second malignancy as a cause of death.
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    Journal Title
    Internal Medicine Journal
    Volume
    50
    Issue
    2
    DOI
    https://doi.org/10.1111/imj.14395
    Copyright Statement
    © 2020 Royal Australasian College of Physicians. This is the peer reviewed version of the following article: A 14-year retrospective analysis of indications and outcomes of autologous haemopoietic stem cell transplantation in regional Queensland: a single-centre experience, Internal Medicine Journal, 2020, 50 (2), pp. 214-221, which has been published in final form at https://doi.org/10.1111/imj.14395. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
    Subject
    Cardiovascular medicine and haematology
    Clinical sciences
    Health services and systems
    Public health
    Science & Technology
    Life Sciences & Biomedicine
    Medicine, General & Internal
    General & Internal Medicine
    haemopoietic stem cell transplantation
    Publication URI
    http://hdl.handle.net/10072/396692
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    • Journal articles

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