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dc.contributor.authorRouf, Razina
dc.contributor.authorUddin, Shaikh Jamal
dc.contributor.authorSarker, Dipto Kumer
dc.contributor.authorIslam, Muhammad Torequl
dc.contributor.authorAli, Eunus S
dc.contributor.authorShilpi, Jamil A
dc.contributor.authorNahar, Lutfun
dc.contributor.authorTiralongo, Evelin
dc.contributor.authorSarker, Satyajit D
dc.date.accessioned2020-08-31T05:35:20Z
dc.date.available2020-08-31T05:35:20Z
dc.date.issued2020
dc.identifier.issn0924-2244
dc.identifier.doi10.1016/j.tifs.2020.08.006
dc.identifier.urihttp://hdl.handle.net/10072/396930
dc.description.abstractBackground: Garlic (Allium sativum L.) is a common herb consumed worldwide as functional food and traditional remedy for the prevention of infectious diseases since ancient time. Garlic and its active organosulfur compounds (OSCs) have been reported to alleviate a number of viral infections in pre-clinical and clinical investigations. However, so far no systematic review on its anti-viral effects and the underlying molecular mechanisms exists. Scope and approach: The aim of this review is to systematically summarize pre-clinical and clinical investigations on antiviral effects of garlic and its OSCs as well as to further analyse recent findings on the mechanisms that underpin these antiviral actions. PubMed, Cochrane library, Google Scholar and Science Direct databases were searched and articles up to June 2020 were included in this review. Key findings and conclusions: Pre-clinical data demonstrated that garlic and its OSCs have potential antiviral activity against different human, animal and plant pathogenic viruses through blocking viral entry into host cells, inhibiting viral RNA polymerase, reverse transcriptase, DNA synthesis and immediate-early gene 1(IEG1) transcription, as well as through downregulating the extracellular-signal-regulated kinase (ERK)/mitogen activated protein kinase (MAPK) signaling pathway. The alleviation of viral infection was also shown to link with immunomodulatory effects of garlic and its OSCs. Clinical studies further demonstrated a prophylactic effect of garlic in the prevention of widespread viral infections in humans through enhancing the immune response. This review highlights that garlic possesses significant antiviral activity and can be used prophylactically in the prevention of viral infections.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofjournalTrends in Food Science & Technology
dc.subject.fieldofresearchFood sciences
dc.subject.fieldofresearchcode3006
dc.subject.keywordsAGE, Aged garlic extract
dc.subject.keywordsAIV-H9N2, Avian influenza virus-H9N2
dc.subject.keywordsALT, Alanine aminotransferase
dc.subject.keywordsARVI, Acute respiratory viral infection
dc.subject.keywordsAdV-3, Adenovirus-3
dc.titleAnti-viral potential of garlic (Allium sativum) and it's organosulfur compounds: A systematic update of pre-clinical and clinical data
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationRouf, R; Uddin, SJ; Sarker, DK; Islam, MT; Ali, ES; Shilpi, JA; Nahar, L; Tiralongo, E; Sarker, SD, Anti-viral potential of garlic (Allium sativum) and it's organosulfur compounds: A systematic update of pre-clinical and clinical data., Trends in Food Science & Technology, 2020
dcterms.dateAccepted2020-08-08
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2020-08-31T04:13:12Z
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.rights.copyright© 2020 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorTiralongo, Evelin
gro.griffith.authorUddin, Shaikh J.


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