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  • Innovative Precision Gene-Editing Tools in Personalized Cancer Medicine

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    Ostrikov422800-Published.pdf (1.178Mb)
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    Author(s)
    Dai, Xiaofeng
    Blancafort, Pilar
    Wang, Peiyu
    Sgro, Agustin
    Thompson, Erik W
    Ostrikov, Kostya Ken
    Griffith University Author(s)
    Ostrikov, Ken
    Year published
    2020
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    Abstract
    The development of clustered regularly interspaced short palindromic repeats (CRISPR) has spurred a successive wave of genome‐engineering following zinc finger nucleases and transcription activator‐like effector nucleases, and made gene‐editing a promising strategy in the prevention and treatment of genetic diseases. However, gene‐editing is not widely adopted in clinics due to some technical issues that challenge its safety and efficacy, and the lack of appropriate clinical regulations allowing them to advance toward improved human health without impinging on human ethics. By systematically examining the oncological ...
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    The development of clustered regularly interspaced short palindromic repeats (CRISPR) has spurred a successive wave of genome‐engineering following zinc finger nucleases and transcription activator‐like effector nucleases, and made gene‐editing a promising strategy in the prevention and treatment of genetic diseases. However, gene‐editing is not widely adopted in clinics due to some technical issues that challenge its safety and efficacy, and the lack of appropriate clinical regulations allowing them to advance toward improved human health without impinging on human ethics. By systematically examining the oncological applications of gene‐editing tools and critical factors challenging their medical translation, genome‐editing has substantial contributions to cancer driver gene discovery, tumor cell epigenome normalization, targeted delivery, cancer animal model establishment, and cancer immunotherapy and prevention in clinics. Gene‐editing tools, epitomized by CRISPR, are predicted to represent a promising strategy toward the precise control of cancer initiation and development. However, some technical problems and ethical concerns are serious issues that need to be appropriately addressed before CRISPR can be incorporated into the next generation of molecular precision medicine. In this light, new technical developments to limit off‐target effects are discussed herein, and the use of gene‐editing approaches for treating otherwise incurable cancers is brought into focus.
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    Journal Title
    Advanced Science
    Volume
    7
    Issue
    12
    DOI
    https://doi.org/10.1002/advs.201902552
    Copyright Statement
    © 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
    Subject
    Nanotechnology
    Science & Technology
    Physical Sciences
    Chemistry, Multidisciplinary
    Nanoscience
    Publication URI
    http://hdl.handle.net/10072/396992
    Collection
    • Journal articles

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