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dc.contributor.authorLeith, David Alexander
dc.contributor.authorMpofu, Buhlebethu Sukoluhle
dc.contributor.authorvan Velden, Julia Laura
dc.contributor.authorReed, Cecile Catharine
dc.contributor.authorvan Boom, Kathryn Merle
dc.contributor.authorBreed, Dorothy
dc.contributor.authorKohn, Tertius Abraham
dc.date.accessioned2020-09-02T08:56:27Z
dc.date.available2020-09-02T08:56:27Z
dc.date.issued2020
dc.identifier.issn1095-6433
dc.identifier.doi10.1016/j.cbpa.2020.110794
dc.identifier.urihttp://hdl.handle.net/10072/397037
dc.description.abstractResearchers, managers and conservationists in the Cape Peninsula, South Africa, have reported cases of individual baboons (Papio ursinus) appearing overweight, lethargic and having poor teeth. Despite an intensive baboon management programme, there are certain individual baboons and troops that continue to raid human food sources. These food sources often are high in processed carbohydrates and saturated fats. As this diet is highly associated with obesity, insulin resistance and type II diabetes, the present study aimed to establish if these baboons may be at risk of developing insulin resistance. Post mortem muscle samples from 17 Cape Peninsula and 7 control adult male baboons were rapidly frozen in liquid nitrogen and analysed for insulin receptor substrate-1 (IRS-1), glucose transporter 4 (GLUT4), oxidative and glycolytic markers of metabolism (citrate synthase, 3-hydroxyacyl-CoA-dehydrogenase, lactate dehydrogenase and creatine kinase activities), and muscle fibre morphology. The sampled Peninsula baboons were heavier (33 ± 2 vs. 29 ± 2 kg, P < 0.05) and had a higher frequency of poor teeth compared to control baboons. Muscle fibre type, fibre size, GLUT4 content, oxidative and glycolytic metabolism were not different between the two groups. However, IRS-1 content, a marker of insulin sensitivity, was significantly lower (by 43%, P < 0.001) in the Peninsula baboons compared to the controls. This study provides the first indirect evidence that some Peninsula baboons with a history of raiding human food sources, may be at risk of developing insulin resistance in the wild, with long term implications for population health.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom110794
dc.relation.ispartofjournalComparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
dc.relation.ispartofvolume250
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3109
dc.subject.keywordsCross-sectional area
dc.subject.keywordsMitochondria
dc.subject.keywordsObesity
dc.subject.keywordsPrimate
dc.subject.keywordsWild animal
dc.titleAre Cape Peninsula baboons raiding their way to obesity and type II diabetes? - a comparative study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationLeith, DA; Mpofu, BS; van Velden, JL; Reed, CC; van Boom, KM; Breed, D; Kohn, TA, Are Cape Peninsula baboons raiding their way to obesity and type II diabetes? - a comparative study, Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2020, 250, pp. 110794
dcterms.dateAccepted2020-08-16
dc.date.updated2020-09-02T03:20:52Z
gro.hasfulltextNo Full Text
gro.griffith.authorvan Velden, Julia L.


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