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dc.contributor.authorCox, AJ
dc.contributor.authorCripps, AW
dc.contributor.authorTaylor, PA
dc.contributor.authorFitton, JH
dc.contributor.authorWest, NP
dc.date.accessioned2020-09-04T01:39:39Z
dc.date.available2020-09-04T01:39:39Z
dc.date.issued2020
dc.identifier.issn1660-3397
dc.identifier.doi10.3390/md18080412
dc.identifier.urihttp://hdl.handle.net/10072/397066
dc.description.abstractNutritional strategies to help promote immune competence are of particular interest for a range of population groups. This study aimed to assess the potential impacts of fucoidan, a seaweed-derived bioactive polysaccharide, on gut markers of immunity and inflammation. A group of professional team-sport athletes were selected for inclusion in the study given the recognized potential for intense physical activity to induce alterations in immune function. A retrospective analysis was performed on stored fecal samples which had been collected from professional team-sport athletes (n = 22) and healthy adults (n = 11) before and after seven days of supplementation with fucoidan (Fucus vesiculosus/Undaria pinnatifida extract, 1 g/d). Fecal concentrations of calprotectin, secretory immunoglobulin A (sIgA) and lysozyme were determined using enzyme-linked immunosorbent assays. The supplement was well tolerated by participants with no adverse events reported. At baseline, fecal lysozyme concentrations were ~73% higher in the healthy adults compared to the professional athletes (p = 0.001). For the professional athletes, a significant (~45%) increase in fecal lysozyme was observed following the supplementation period (p = 0.001). These data suggest that fucoidan supplementation may have the potential to promote the secretion of antimicrobial peptides in specific population groups and contribute to the regulation of mucosal immune health.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute
dc.relation.ispartofpagefrom412
dc.relation.ispartofpageto412
dc.relation.ispartofissue8
dc.relation.ispartofjournalMarine drugs
dc.relation.ispartofvolume18
dc.subject.fieldofresearchPhysical chemistry
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3406
dc.subject.fieldofresearchcode3214
dc.subject.keywordsathletes
dc.subject.keywordsfucoidan
dc.subject.keywordsgut
dc.subject.keywordslysozyme
dc.subject.keywordsmucosa
dc.titleFucoidan Supplementation Restores Fecal Lysozyme Concentrations in High-Performance Athletes: A Pilot Study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationCox, AJ; Cripps, AW; Taylor, PA; Fitton, JH; West, NP, Fucoidan Supplementation Restores Fecal Lysozyme Concentrations in High-Performance Athletes: A Pilot Study, Marine drugs, 2020, 18 (8), pp. 412-412
dcterms.dateAccepted2020-08-03
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-09-03T05:10:58Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020 The Authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorCripps, Allan W.
gro.griffith.authorCox, Amanda J.
gro.griffith.authorWest, Nic P.


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