• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Display of Native Antigen on cDC1 That Have Spatial Access to Both T and B Cells Underlies Efficient Humoral Vaccination

    Thumbnail
    View/Open
    Zaid441292Published.pdf (818.4Kb)
    File version
    Version of Record (VoR)
    Author(s)
    Kato, Yu
    Steiner, Thiago M
    Park, Hae-Young
    Hitchcock, Rohan O
    Zaid, Ali
    Hor, Jyh Liang
    Devi, Sapna
    Davey, Gayle M
    Vremec, David
    Tullett, Kirsteen M
    Tan, Peck S
    Ahmet, Fatma
    Mueller, Scott N
    Alonso, Sylvie
    Tarlinton, David M
    Ploegh, Hidde L
    Kaisho, Tsuneyasu
    Beattie, Lynette
    Manton, Jonathan H
    Fernandez-Ruiz, Daniel
    Shortman, Ken
    Lahoud, Mireille H
    Heath, William R
    Caminschi, Irina
    Griffith University Author(s)
    Zaid, Ali
    Year published
    2020
    Metadata
    Show full item record
    Abstract
    Follicular dendritic cells and macrophages have been strongly implicated in presentation of native Ag to B cells. This property has also occasionally been attributed to conventional dendritic cells (cDC) but is generally masked by their essential role in T cell priming. cDC can be divided into two main subsets, cDC1 and cDC2, with recent evidence suggesting that cDC2 are primarily responsible for initiating B cell and T follicular helper responses. This conclusion is, however, at odds with evidence that targeting Ag to Clec9A (DNGR1), expressed by cDC1, induces strong humoral responses. In this study, we reveal that murine ...
    View more >
    Follicular dendritic cells and macrophages have been strongly implicated in presentation of native Ag to B cells. This property has also occasionally been attributed to conventional dendritic cells (cDC) but is generally masked by their essential role in T cell priming. cDC can be divided into two main subsets, cDC1 and cDC2, with recent evidence suggesting that cDC2 are primarily responsible for initiating B cell and T follicular helper responses. This conclusion is, however, at odds with evidence that targeting Ag to Clec9A (DNGR1), expressed by cDC1, induces strong humoral responses. In this study, we reveal that murine cDC1 interact extensively with B cells at the border of B cell follicles and, when Ag is targeted to Clec9A, can display native Ag for B cell activation. This leads to efficient induction of humoral immunity. Our findings indicate that surface display of native Ag on cDC with access to both T and B cells is key to efficient humoral vaccination.
    View less >
    Journal Title
    Journal of Immunology
    DOI
    https://doi.org/10.4049/jimmunol.2000549
    Copyright Statement
    © 2020 by The American Association of Immunologists, Inc. This article is distributed under The American Association of Immunologists, Inc., Reuse Terms and Conditions for Author Choice articles.
    Subject
    Immunology
    Publication URI
    http://hdl.handle.net/10072/397074
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander