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dc.contributor.authorAu-Yeung, Yin To
dc.contributor.authorChang, Anne B
dc.contributor.authorGrimwood, Keith
dc.contributor.authorLovie-Toon, Yolanda
dc.contributor.authorKaus, Michelle
dc.contributor.authorRablin, Sheree
dc.contributor.authorArnold, Dan
dc.contributor.authorRoberts, Jack
dc.contributor.authorParfitt, Sarah
dc.contributor.authorAnderson, Jennie
dc.contributor.authorToombs, Maree
dc.contributor.authorO'Grady, Kerry-Ann F
dc.date.accessioned2020-09-07T01:32:31Z
dc.date.available2020-09-07T01:32:31Z
dc.date.issued2020
dc.identifier.issn2296-2360
dc.identifier.doi10.3389/fped.2020.00444
dc.identifier.urihttp://hdl.handle.net/10072/397130
dc.description.abstractBackground and Objective: Data on the predictors of chronic cough development in young children are scarce. Our primary objective was to examine the factors associated with young children developing a chronic cough, with a focus on childcare attendance. Methods: A secondary analysis of data collected in a prospective cohort study of children presenting to three emergency departments and three primary healthcare centers in southeast Queensland, Australia. Eligible children where those aged <6-years presenting with cough and without known underlying chronic lung disease other than asthma. Children were followed for 4 weeks to ascertain cough duration. The primary outcome was persistent cough at day-28. Logistic regression models were undertaken to identify independent predictors of chronic cough including sensitivity analyses that accounted for children with unknown cough status at day-28. Results: In 362 children, 95 (26.2%) were classified as having chronic cough. In models that included only children for whom cough status was known at day-28, symptom duration at enrolment, age <12 months [adjusted odds ratio (aOR) 4.5, 95% confidence interval (CI) 1.1, 18.7], gestational age (aOR 3.2, 95%CI 1.4, 7.9), underlying medical conditions (aOR 2.6, 95% CI 1.3, 5.5), a history of wheeze (aOR 2.6, 95% CI 1.4, 4.8) and childcare attendance (aOR 2.3, 95% CI 1.2, 4.4) were independent predictors of chronic cough. Amongst childcare attendees only, 64 (29.8%) had chronic cough at day-28. The strongest predictor of chronic cough amongst childcare attendees was continued attendance at childcare during their illness (aOR = 12.9, 95% CI 3.9, 43.3). Conclusion: Gestational age, underlying medical conditions, prior wheeze and childcare attendance are risk factors for chronic cough in young children. Parents/careers need to be aware of the risks associated with their child continuing to attend childcare whilst unwell and childcare centers should reinforce prevention measures in their facilities.
dc.description.peerreviewedYes
dc.publisherFrontiers Media SA
dc.relation.ispartofpagefrom444
dc.relation.ispartofjournalFrontiers in Pediatrics
dc.relation.ispartofvolume8
dc.subject.fieldofresearchOther health sciences
dc.subject.fieldofresearchcode4299
dc.titleRisk Factors for Chronic Cough in Young Children: A Cohort Study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationAu-Yeung, YT; Chang, AB; Grimwood, K; Lovie-Toon, Y; Kaus, M; Rablin, S; Arnold, D; Roberts, J; Parfitt, S; Anderson, J; Toombs, M; O'Grady, K-AF, Risk Factors for Chronic Cough in Young Children: A Cohort Study, Frontiers in Pediatrics, 8, pp. 444
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-09-07T01:23:04Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020 Au-Yeung, Chang, Grimwood, Lovie-Toon, Kaus, Rablin, Arnold, Roberts, Parfitt, Anderson, Toombs and O'Grady. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
gro.hasfulltextFull Text
gro.griffith.authorGrimwood, Keith


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