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  • Leptanoine D, a New Quinoline Alkaloid from the Australian Tree Pitaviaster haplophyllus (Rutaceae)

    Author(s)
    Robertson, Luke P
    Makwana, Vivek
    Voser, Tanja M
    Holland, Darren C
    Carroll, Anthony R
    Griffith University Author(s)
    Carroll, Anthony R.
    Voser, Tanja M.
    Holland, Darren C.
    Makwana, Vivek M.
    Year published
    2020
    Metadata
    Show full item record
    Abstract
    One new furoquinoline alkaloid, leptanoine D (1) and nine known alkaloids 2–10 were isolated from Pitaviaster haplophyllus. Leptanoine D (1) contains a typically unstable vinyl ether moiety and was structurally elucidated based on 2D NMR, (+)-HR-ESI-MS, and ECD data. The structures of the known furoquinoline alkaloids leptanoine A (11) and B (12) have also been revised. Compounds 1–10 were screened against three species of bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli), however they showed no activity at the highest dose tested (32 µg mL−1). The compounds were also evaluated for anti-proliferative ...
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    One new furoquinoline alkaloid, leptanoine D (1) and nine known alkaloids 2–10 were isolated from Pitaviaster haplophyllus. Leptanoine D (1) contains a typically unstable vinyl ether moiety and was structurally elucidated based on 2D NMR, (+)-HR-ESI-MS, and ECD data. The structures of the known furoquinoline alkaloids leptanoine A (11) and B (12) have also been revised. Compounds 1–10 were screened against three species of bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli), however they showed no activity at the highest dose tested (32 µg mL−1). The compounds were also evaluated for anti-proliferative action against PC-3 and WPMY-1 cells, with 7–9 displaying weak activity at 100 μM.
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    Journal Title
    Australian Journal of Chemistry
    DOI
    https://doi.org/10.1071/CH20125
    Note
    This publication has been entered in Griffith Research Online as an advanced online version.
    Subject
    Chemical Sciences
    Science & Technology
    Physical Sciences
    Chemistry, Multidisciplinary
    Chemistry
    FUROQUINOLINE ALKALOIDS
    Publication URI
    http://hdl.handle.net/10072/397346
    Collection
    • Journal articles

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