• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Bis(imidazol-1-yl)methane-based heteroscorpionate metal(II) complexes: Theoretical, antimicrobial, antioxidant, in vitro cytotoxicity and c-Met tyrosine kinase studies

    Author(s)
    Jayakumar, S
    Mahendiran, D
    Arumai Selvan, D
    Kalilur Rahiman, A
    Griffith University Author(s)
    Dharmasivam, Mahendiran
    Year published
    2019
    Metadata
    Show full item record
    Abstract
    The C-centered bis(imidazol-1-yl)methane-based heteroscorpionate metal(II) complexes of the type [M(L1−3)Cl] (1–9), where M = Mn(II), Ni(II) or Cu(II) have been synthesized using the heteroscorpionate ligands, (2-hydroxyphenyl)bis(imidazol-1-yl)methane (HL1), (4-diethylamino-2-hydroxyphenyl)bis(imidazol-1-yl)methane (HL2) and (5-bromo-2-hydroxyphenyl)bis(imidazol-1-yl)methane (HL3). The spectral and theoretical studies suggested tetrahedral geometry for manganese(II) and nickel(II) complexes, and square-planar geometry for copper(II) complexes. The antimicrobial activity of the complexes was evaluated against two Gram (–ve) ...
    View more >
    The C-centered bis(imidazol-1-yl)methane-based heteroscorpionate metal(II) complexes of the type [M(L1−3)Cl] (1–9), where M = Mn(II), Ni(II) or Cu(II) have been synthesized using the heteroscorpionate ligands, (2-hydroxyphenyl)bis(imidazol-1-yl)methane (HL1), (4-diethylamino-2-hydroxyphenyl)bis(imidazol-1-yl)methane (HL2) and (5-bromo-2-hydroxyphenyl)bis(imidazol-1-yl)methane (HL3). The spectral and theoretical studies suggested tetrahedral geometry for manganese(II) and nickel(II) complexes, and square-planar geometry for copper(II) complexes. The antimicrobial activity of the complexes was evaluated against two Gram (–ve) (Shigella dysenteriae and Vibrio cholerae) and two Gram (+ve) (Bacillus cereus and Streptococcus faecalis) bacterial, and three fungal (Candida albicans, Candida glabrata and Candida krusei) strains. The antioxidant activity of the ligands and their nickel(II) and copper(II) complexes were determined by ABTS, DPPH and H2O2 free radical scavenging assays. In vitro cytotoxicity activity of the ligands and their nickel(II) and copper(II) complexes were tested against human breast adenocarcinoma (MCF-7), cervical (HeLa) and lung (A549) cancerous and normal human dermal fibroblast (NHDF) cell lines by MTT reduction assay. The copper(II) complex 8 exhibit higher cytotoxicity activity than the other complexes against all the tested cancer cell lines. Molecular docking studies of the complexes were also performed with c-Met tyrosine kinase receptor to determine the possible binding mode and predominant binding interactions.
    View less >
    Journal Title
    Journal of Molecular Structure
    Volume
    1196
    DOI
    https://doi.org/10.1016/j.molstruc.2019.06.088
    Subject
    Physical chemistry
    Theoretical and computational chemistry
    Publication URI
    http://hdl.handle.net/10072/397353
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E
    • TEQSA: PRV12076

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander