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  • The pathogenesis of mucositis: updated perspectives and emerging targets

    Author(s)
    Bowen, J
    Al-Dasooqi, N
    Bossi, P
    Wardill, H
    van Sebille, Y
    Al-Azri, A
    Bateman, E
    Correa, ME
    Raber-Durlacher, J
    Kandwal, A
    Mayo, B
    Nair, RG
    Stringer, A
    ten Bohmer, K
    Thorpe, D
    Lalla, RV
    Sonis, S
    Cheng, K
    Elad, S
    Griffith University Author(s)
    Nair, Raj
    Year published
    2019
    Metadata
    Show full item record
    Abstract
    Mucositis research and treatment are a rapidly evolving field providing constant new avenues of research and potential therapies. The MASCC/ISOO Mucositis Study Group regularly assesses available literature relating to pathogenesis, mechanisms, and novel therapeutic approaches and distils this to summary perspectives and recommendations. Reviewers assessed 164 articles published between January 2011 and June 2016 to identify progress made since the last review and highlight new targets for further investigation. Findings were organized into sections including established and emerging mediators of toxicity, potential insights ...
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    Mucositis research and treatment are a rapidly evolving field providing constant new avenues of research and potential therapies. The MASCC/ISOO Mucositis Study Group regularly assesses available literature relating to pathogenesis, mechanisms, and novel therapeutic approaches and distils this to summary perspectives and recommendations. Reviewers assessed 164 articles published between January 2011 and June 2016 to identify progress made since the last review and highlight new targets for further investigation. Findings were organized into sections including established and emerging mediators of toxicity, potential insights from technological advances in mucositis research, and perspective. Research momentum is accelerating for mucositis pathogenesis, and with this has come utilization of new models and interventions that target specific mechanisms of injury. Technological advances have the potential to revolutionize the field of mucositis research, although focused effort is needed to move rationally targeted interventions to the clinical setting.
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    Journal Title
    Supportive Care in Cancer
    Volume
    27
    Issue
    10
    DOI
    https://doi.org/10.1007/s00520-019-04893-z
    Subject
    Medical and Health Sciences
    Psychology and Cognitive Sciences
    Science & Technology
    Life Sciences & Biomedicine
    Oncology
    Health Care Sciences & Services
    Rehabilitation
    Publication URI
    http://hdl.handle.net/10072/397380
    Collection
    • Journal articles

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