• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Beyond oxygen transport: Active role of erythrocytes in the regulation of blood flow

    Author(s)
    Richardson, Kieran J
    Kuck, Lennart
    Simmonds, Michael J
    Griffith University Author(s)
    Simmonds, Michael J.
    Kuck, Lennart L.
    Year published
    2020
    Metadata
    Show full item record
    Abstract
    It was classically thought that the function of mammalian red blood cells (RBC) was limited to serving as a vehicle for oxygen, given the cell's abundance of cytosolic haemoglobin. Over the past decades, however, accumulating evidence indicates that RBC have the capacity to sense low oxygen tensions in hypoxic tissues, and subsequently release signalling molecules that influence the distribution of blood flow. The precise mechanisms that facilitate RBC modulation of blood flow are still being elucidated, although recent evidence indicates involvement of: i) adenosine triphosphate (ATP) - capable of binding to purinergic ...
    View more >
    It was classically thought that the function of mammalian red blood cells (RBC) was limited to serving as a vehicle for oxygen, given the cell's abundance of cytosolic haemoglobin. Over the past decades, however, accumulating evidence indicates that RBC have the capacity to sense low oxygen tensions in hypoxic tissues, and subsequently release signalling molecules that influence the distribution of blood flow. The precise mechanisms that facilitate RBC modulation of blood flow are still being elucidated, although recent evidence indicates involvement of: i) adenosine triphosphate (ATP) - capable of binding to purinergic receptors located on the vascular wall prior to initiating nitric oxide (NO; a powerful vasodilator) production in endothelial cells, and/or ii) non-vascular NO - which is now known to have several modes of production within RBC, including an enzymatic process via a unique isoform of NO synthase (i.e., RBC-NOS), that has potential effects on the vascular smooth muscle. The physical properties of RBC - including their tendency to form three-dimensional structures in low shear flow (i.e., aggregation) and their capacity to elongate in high shear flow (i.e., deformability) - are only recently being viewed as mechanotransductive processes, with profound effects on vascular reactivity and tissue perfusion. Recent developments in intracellular signalling in RBC, and the subsequent effects on the mechanical properties of blood, and blood flow, thus present a vivid expansion on the classic perspective of these abundant cells.
    View less >
    Journal Title
    American Journal of Physiology: Heart and Circulatory Physiology
    DOI
    https://doi.org/10.1152/ajpheart.00441.2020
    Note
    This publication has been entered in Griffith Research Online as an advanced online version.
    Subject
    Zoology
    Medical physiology
    ATP
    Circulation
    Red blood cells
    Tissue perfusion
    Vasoreactivity
    Publication URI
    http://hdl.handle.net/10072/397468
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E
    • TEQSA: PRV12076

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander