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  • Two new betaines from the Australian bryozoan Amathia lamourouxi

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    Embargoed until: 2021-08-14
    Author(s)
    Voser, Tanja M
    Hayton, Joshua B
    Robertson, Luke P
    Carroll, Anthony R
    Griffith University Author(s)
    Carroll, Anthony R.
    Voser, Tanja M.
    Hayton, Joshua B.
    Robertson, Luke P.
    Year published
    2019
    Metadata
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    Abstract
    A chemical investigation of the eastern Australian endemic bryozoan Amathia lamourouxi led to the isolation of two unique betaine molecules, lamouroic acid trifluoroacetate and lamourimidazolinium trifluoroacetate. The structures of these molecules were determined using (+)-HRESIMS, 2D NMR and ECD analyses. The new compounds were screened for antiplasmodial, cytotoxic and antibacterial activity but were inactive at 40 μM. Lamouroic acid trifluoroacetate is structurally related to the ubiquitous marine compound homarine, that has previously been shown to possess feeding deterrent properties, and this suggests that the new ...
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    A chemical investigation of the eastern Australian endemic bryozoan Amathia lamourouxi led to the isolation of two unique betaine molecules, lamouroic acid trifluoroacetate and lamourimidazolinium trifluoroacetate. The structures of these molecules were determined using (+)-HRESIMS, 2D NMR and ECD analyses. The new compounds were screened for antiplasmodial, cytotoxic and antibacterial activity but were inactive at 40 μM. Lamouroic acid trifluoroacetate is structurally related to the ubiquitous marine compound homarine, that has previously been shown to possess feeding deterrent properties, and this suggests that the new compound may also have an ecological role in the bryozoan.
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    Journal Title
    Tetrahedron Letters
    Volume
    60
    Issue
    38
    DOI
    https://doi.org/10.1016/j.tetlet.2019.151047
    Copyright Statement
    © 2019 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
    Subject
    Medicinal and Biomolecular Chemistry
    Organic Chemistry
    Science & Technology
    Physical Sciences
    Chemistry, Organic
    Chemistry
    Amathia lamourouxi
    Publication URI
    http://hdl.handle.net/10072/397503
    Collection
    • Journal articles

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