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  • Antimicrobial photodynamic therapy improves the alveolar repair process and prevents the occurrence of osteonecrosis of the jaws after tooth extraction in senile rats treated with zoledronate

    Author(s)
    Ervolino, Edilson
    Statkievicz, Cristian
    Toro, Luan Felipe
    de Mello-Neto, Joao Martins
    Cavazana, Thamires Priscila
    Mardegan Issa, Joao Paulo
    Menegati Dornelles, Rita Cassia
    de Almeida, Juliano Milanezi
    Hitomi Nagata, Maria Jose
    Okamoto, Roberta
    Casatti, Claudio Aparecido
    Garcia, Valdir Gouveia
    Theodoro, Leticia Helena
    Griffith University Author(s)
    Martins De Mello Neto, Joao M.
    Year published
    2019
    Metadata
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    Abstract
    This study evaluated the effects of antimicrobial photodynamic therapy (aPDT) in the alveolar repair of rats with major risk factors for bisphosphonate-related osteonecrosis of the jaws (BRONJ). Senile rats received 0.45 ml of vehicle (VEH and VEH/aPDT) or 0.45 ml of zoledronate (ZOL and ZOL/aPDT) every three days for seven weeks. After three weeks of treatment, the first lower left molar was extracted. VEH/aPDT and ZOL/aPDT were submitted to aPDT on the extraction site at 0, 2 and 4 days postoperatively. Euthanasia was performed 28 days postoperatively and the extraction site was evaluated by clinical, histological, ...
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    This study evaluated the effects of antimicrobial photodynamic therapy (aPDT) in the alveolar repair of rats with major risk factors for bisphosphonate-related osteonecrosis of the jaws (BRONJ). Senile rats received 0.45 ml of vehicle (VEH and VEH/aPDT) or 0.45 ml of zoledronate (ZOL and ZOL/aPDT) every three days for seven weeks. After three weeks of treatment, the first lower left molar was extracted. VEH/aPDT and ZOL/aPDT were submitted to aPDT on the extraction site at 0, 2 and 4 days postoperatively. Euthanasia was performed 28 days postoperatively and the extraction site was evaluated by clinical, histological, histometric, histochemical and immunohistochemical analysis. ZOL showed tissue repair impairment; lower percentage of newly formed bone tissue (NFBT); higher percentage of non-vital bone tissue (NVBT); fewer mature collagen fibers and increased immunolabeling for tumor necrosis factor (TNFα), interleukin (IL)-1β and IL-6. ZOL/aPDT showed clinical and histological characteristics of the extraction site, percentage of NFBT and percentage of mature collagen fiber similar to VEH. Percentage of NVBT and immunolabeling for inflammatory cytokines in ZOL/aPDT was lower than in ZOL. Immunolabeling for tartarato-resistant acid phosphatase (TRAP) was lower in ZOL and ZOL/aPDT. aPDT in the dental extraction site improves tissue repair process and prevents the occurrence of BRONJ-like lesions after tooth extraction.
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    Journal Title
    Bone
    Volume
    120
    DOI
    https://doi.org/10.1016/j.bone.2018.10.014
    Subject
    Biological Sciences
    Engineering
    Medical and Health Sciences
    Science & Technology
    Life Sciences & Biomedicine
    Endocrinology & Metabolism
    Bisphosphonate-related osteonecrosis of the jaws
    Photochemotherapy
    Publication URI
    http://hdl.handle.net/10072/397556
    Collection
    • Journal articles

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