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  • Application of Autologous Platelet-Rich Plasma on Tooth Extraction Site Prevents Occurence of Medication-Related Osteonecrosis of the Jaws in Rats

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    Author(s)
    Toro, Luan Felipe
    de Mello-Neto, Joao Martins
    Ventura dos Santos, Fernanda Furuse
    Ferreira, Leticia Chaves
    Statkievicz, Cristian
    Angelo Cintra, Luciano Tavares
    Mardegan Issa, Joao Paulo
    Menegati Dornelles, Rita Cassia
    de Almeida, Juliano Milanezi
    Hitomi Nagata, Maria Jose
    Garcia, Valdir Gouveia
    Theodoro, Leticia Helena
    Casatti, Claudio Aparecido
    Ervolino, Edilson
    Griffith University Author(s)
    Martins De Mello Neto, Joao M.
    Year published
    2019
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    Abstract
    This study evaluated the effects of local application of autologous platelet-rich plasma (PRP) on the tooth extraction site of rats presenting the main risk factors for medication-related osteonecrosis of the jaw (MRONJ). For seven weeks, senile rats were submitted to systemic treatment with vehicle (VEH and VEH-PRP) or 100 μg/Kg of zoledronate (ZOL and ZOL-PRP) every three days. After three weeks, the first lower molar was extracted. VEH-PRP and ZOL-PRP received PRP at the tooth extraction site. Euthanasia was performed at 28 days postoperatively. Clinical, histopathological, histometric and immunohistochemical analyses ...
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    This study evaluated the effects of local application of autologous platelet-rich plasma (PRP) on the tooth extraction site of rats presenting the main risk factors for medication-related osteonecrosis of the jaw (MRONJ). For seven weeks, senile rats were submitted to systemic treatment with vehicle (VEH and VEH-PRP) or 100 μg/Kg of zoledronate (ZOL and ZOL-PRP) every three days. After three weeks, the first lower molar was extracted. VEH-PRP and ZOL-PRP received PRP at the tooth extraction site. Euthanasia was performed at 28 days postoperatively. Clinical, histopathological, histometric and immunohistochemical analyses were carried out in histological sections from the tooth extraction site. ZOL showed lower percentage of newly formed bone tissue (NFBT), higher percentage of non-vital bone tissue (NVBT), as well as higher immunolabeling for TNFα and IL-1β. In addition, ZOL presented lower immunolabeling for PCNA, VEGF, BMP2/4, OCN and TRAP. VEH and ZOL-PRP showed improvement in the tooth extraction site wound healing and comparable percentage of NFBT, VEGF, BMP2/4 and OCN. Local application of autologous PRP proved a viable preventive therapy, which is safe and effective to restore tissue repair capacity of the tooth extraction site and prevent the occurrence of MRONJ following tooth extraction.
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    Journal Title
    Scientific Reports
    Volume
    9
    Issue
    1
    DOI
    https://doi.org/10.1038/s41598-018-37063-y
    Copyright Statement
    © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
    Subject
    Dentistry
    Science & Technology
    Multidisciplinary Sciences
    Science & Technology - Other Topics
    BISPHOSPHONATE-RELATED OSTEONECROSIS
    ZOLEDRONIC ACID
    Publication URI
    http://hdl.handle.net/10072/397557
    Collection
    • Journal articles

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