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  • A microfluidic concentration gradient generator for simultaneous delivery of two reagents on a millimeter-sized sample

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    Embargoed until: 2021-07-07
    Author(s)
    Rismanian, Milad
    Saidi, Mohammad Said
    Kashaninejad, Navid
    Griffith University Author(s)
    Kashaninejad, Navid 0.
    Year published
    2020
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    Abstract
    Microfluidic concentration gradient generators (μCGGs) are indispensable parts of many emerging lab-on-a-chip platforms for biological studies and drug delivery applications. Most of the μCGGs reported in the literature can only generate the desired concentration gradients in a micron-sized sample (e.g., cells). As such, there is an unmet need to design a μCGG that can generate continuous concentration gradients of multi reagents (e.g., drugs) in a millimeter-sized sample (e.g., tissue). Herein, we report the proof-of-concept of this class of μCGG by combining a modified tree-like CGG with a micromixer. By conducting both ...
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    Microfluidic concentration gradient generators (μCGGs) are indispensable parts of many emerging lab-on-a-chip platforms for biological studies and drug delivery applications. Most of the μCGGs reported in the literature can only generate the desired concentration gradients in a micron-sized sample (e.g., cells). As such, there is an unmet need to design a μCGG that can generate continuous concentration gradients of multi reagents (e.g., drugs) in a millimeter-sized sample (e.g., tissue). Herein, we report the proof-of-concept of this class of μCGG by combining a modified tree-like CGG with a micromixer. By conducting both experimental investigation and numerical analysis, we show that the proposed device can generate a continuous concentration gradient of two reagents and deliver all the possible combinations of their concentrations to a millimeter-sized sample. The proposed device can be used in a broad range of applications, especially ex-vivo drug chemosensitivity testing in personalized medicine.
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    Journal Title
    Journal of Flow Chemistry
    DOI
    https://doi.org/10.1007/s41981-020-00104-7
    Copyright Statement
    © 2020 Springer. This is an electronic version of an article published in Journal of Flow Chemistry, 2020. American Journal of Cardiovascular Drugs is available online at: http://link.springer.com/ with the open URL of your article.
    Note
    This publication has been entered in Griffith Research Online as an advanced online version.
    Subject
    Organic Chemistry
    Science & Technology
    Physical Sciences
    Chemistry, Multidisciplinary
    Chemistry
    Micromixer
    Publication URI
    http://hdl.handle.net/10072/397576
    Collection
    • Journal articles

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