dc.contributor.author | Rismanian, Milad | |
dc.contributor.author | Saidi, Mohammad Said | |
dc.contributor.author | Kashaninejad, Navid | |
dc.date.accessioned | 2020-09-18T05:02:57Z | |
dc.date.available | 2020-09-18T05:02:57Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2062-249X | |
dc.identifier.doi | 10.1007/s41981-020-00104-7 | |
dc.identifier.uri | http://hdl.handle.net/10072/397576 | |
dc.description.abstract | Microfluidic concentration gradient generators (μCGGs) are indispensable parts of many emerging lab-on-a-chip platforms for biological studies and drug delivery applications. Most of the μCGGs reported in the literature can only generate the desired concentration gradients in a micron-sized sample (e.g., cells). As such, there is an unmet need to design a μCGG that can generate continuous concentration gradients of multi reagents (e.g., drugs) in a millimeter-sized sample (e.g., tissue). Herein, we report the proof-of-concept of this class of μCGG by combining a modified tree-like CGG with a micromixer. By conducting both experimental investigation and numerical analysis, we show that the proposed device can generate a continuous concentration gradient of two reagents and deliver all the possible combinations of their concentrations to a millimeter-sized sample. The proposed device can be used in a broad range of applications, especially ex-vivo drug chemosensitivity testing in personalized medicine. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Springer | |
dc.relation.ispartofjournal | Journal of Flow Chemistry | |
dc.subject.fieldofresearch | Organic chemistry | |
dc.subject.fieldofresearchcode | 3405 | |
dc.subject.keywords | Science & Technology | |
dc.subject.keywords | Physical Sciences | |
dc.subject.keywords | Chemistry, Multidisciplinary | |
dc.subject.keywords | Chemistry | |
dc.subject.keywords | Micromixer | |
dc.title | A microfluidic concentration gradient generator for simultaneous delivery of two reagents on a millimeter-sized sample | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Rismanian, M; Saidi, MS; Kashaninejad, N, A microfluidic concentration gradient generator for simultaneous delivery of two reagents on a millimeter-sized sample, Journal of Flow Chemistry, 2020 | |
dc.date.updated | 2020-09-16T06:12:50Z | |
dc.description.version | Accepted Manuscript (AM) | |
gro.description.notepublic | This publication has been entered in Griffith Research Online as an advanced online version. | |
gro.rights.copyright | © 2020 Springer. This is an electronic version of an article published in Journal of Flow Chemistry, 2020. American Journal of Cardiovascular Drugs is available online at: http://link.springer.com/ with the open URL of your article. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Kashaninejad, Navid | |