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dc.contributor.authorRismanian, Milad
dc.contributor.authorSaidi, Mohammad Said
dc.contributor.authorKashaninejad, Navid
dc.date.accessioned2020-09-18T05:02:57Z
dc.date.available2020-09-18T05:02:57Z
dc.date.issued2020
dc.identifier.issn2062-249Xen_US
dc.identifier.doi10.1007/s41981-020-00104-7en_US
dc.identifier.urihttp://hdl.handle.net/10072/397576
dc.description.abstractMicrofluidic concentration gradient generators (μCGGs) are indispensable parts of many emerging lab-on-a-chip platforms for biological studies and drug delivery applications. Most of the μCGGs reported in the literature can only generate the desired concentration gradients in a micron-sized sample (e.g., cells). As such, there is an unmet need to design a μCGG that can generate continuous concentration gradients of multi reagents (e.g., drugs) in a millimeter-sized sample (e.g., tissue). Herein, we report the proof-of-concept of this class of μCGG by combining a modified tree-like CGG with a micromixer. By conducting both experimental investigation and numerical analysis, we show that the proposed device can generate a continuous concentration gradient of two reagents and deliver all the possible combinations of their concentrations to a millimeter-sized sample. The proposed device can be used in a broad range of applications, especially ex-vivo drug chemosensitivity testing in personalized medicine.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.language.isoeng
dc.publisherSpringeren_US
dc.relation.ispartofjournalJournal of Flow Chemistryen_US
dc.subject.fieldofresearchOrganic Chemistryen_US
dc.subject.fieldofresearchcode0305en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsPhysical Sciencesen_US
dc.subject.keywordsChemistry, Multidisciplinaryen_US
dc.subject.keywordsChemistryen_US
dc.subject.keywordsMicromixeren_US
dc.titleA microfluidic concentration gradient generator for simultaneous delivery of two reagents on a millimeter-sized sampleen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationRismanian, M; Saidi, MS; Kashaninejad, N, A microfluidic concentration gradient generator for simultaneous delivery of two reagents on a millimeter-sized sample, Journal of Flow Chemistry, 2020en_US
dc.date.updated2020-09-16T06:12:50Z
dc.description.versionAccepted Manuscript (AM)en_US
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.en_US
gro.rights.copyright© 2020 Springer. This is an electronic version of an article published in Journal of Flow Chemistry, 2020. American Journal of Cardiovascular Drugs is available online at: http://link.springer.com/ with the open URL of your article.en_US
gro.hasfulltextFull Text
gro.griffith.authorKashaninejad, Navid 0.


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