Show simple item record

dc.contributor.authorZheng, Tingting
dc.contributor.authorChen, Keke
dc.contributor.authorZhang, Xue
dc.contributor.authorFeng, Huanhuan
dc.contributor.authorShi, Yu
dc.contributor.authorLiu, Li
dc.contributor.authorZhang, Jun
dc.contributor.authorChen, Yun
dc.date.accessioned2020-09-17T03:21:01Z
dc.date.available2020-09-17T03:21:01Z
dc.date.issued2020
dc.identifier.issn1945-4589
dc.identifier.doi10.18632/aging.103915
dc.identifier.urihttp://hdl.handle.net/10072/397601
dc.description.abstractGlioma is the most common malignant brain tumor. Because of its high degree of malignancy, the effect of surgical treatment, radiotherapy, chemotherapy, or immunotherapy is not ideal. TXNDC9 belongs to thioredoxin domain-containing proteins, which is involved in tumor progression. However, no research associated with TXNDC9 has been reported in glioma. In this study, we found that TXNDC9 was upregulated in glioma. Knockdown of TXNDC9 would prevent proliferation and metastasis, induce the apoptosis rate of glioma cells, and promote the expression Cleaved-caspase3, Cleaved-caspase8, Cleaved-caspase9. Meanwhile, knockdown of TXNDC9 induced autophagy by increasing the level of LC3 and Beclin-1. Cell morphology and expression analysis of GFAP, Vimentin, verified that TXNDC9 could regulate glioma cell differentiation. During this program, the expression of p53 changes dramatically. The apoptosis, autophagy, and cell differentiation program were blocked by p53 inhibitor treatment. In conclusion, the silencing of TXNDC9 induces apoptosis and autophagy in glioma and promotes cell differentiation by controlling p53 and may function as a new mechanism in glioma.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherImpact Journals, LLC
dc.relation.ispartofjournalAging
dc.relation.ispartofvolume12
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchPhysiology
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode0606
dc.subject.fieldofresearchcode1112
dc.subject.keywordsTXNDC9
dc.subject.keywordsapoptosis
dc.subject.keywordsautophagy
dc.subject.keywordsdifferentiation
dc.subject.keywordsglioma
dc.titleKnockdown of TXNDC9 induces apoptosis and autophagy in glioma and mediates cell differentiation by p53 activation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationZheng, T; Chen, K; Zhang, X; Feng, H; Shi, Y; Liu, L; Zhang, J; Chen, Y, Knockdown of TXNDC9 induces apoptosis and autophagy in glioma and mediates cell differentiation by p53 activation., Aging, 2020, 12
dcterms.dateAccepted2020-07-21
dcterms.licensehttps://creativecommons.org/licenses/by/3.0/
dc.date.updated2020-09-17T01:40:47Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020 Zheng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
gro.hasfulltextFull Text
gro.griffith.authorZhang, Jun


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record