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  • Factors associated with being diagnosed with high severity of breast cancer: a population-based study in Queensland, Australia

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    Embargoed until: 2021-09-14
    Author(s)
    Kou, Kou
    Cameron, Jessica
    Aitken, Joanne F
    Youl, Philippa
    Turrell, Gavin
    Chambers, Suzanne
    Dunn, Jeff
    Pyke, Chris
    Baade, Peter D
    Griffith University Author(s)
    Baade, Peter D.
    Chambers, Suzanne K.
    Year published
    2020
    Metadata
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    Abstract
    Purpose: This study explores factors that are associated with the severity of breast cancer (BC) at diagnosis. Methods: Interviews were conducted among women (n = 3326) aged 20-79 diagnosed with BC between 2011 and 2013 in Queensland, Australia. High-severity cancers were defined as either Stage II-IV, Grade 3, or having negative hormone receptors at diagnosis. Logistic regression models were used to estimate odds ratios (ORs) of high severity BC for variables relating to screening, lifestyle, reproductive habits, family history, socioeconomic status, and area disadvantage. Results: Symptom-detected women had greater odds ...
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    Purpose: This study explores factors that are associated with the severity of breast cancer (BC) at diagnosis. Methods: Interviews were conducted among women (n = 3326) aged 20-79 diagnosed with BC between 2011 and 2013 in Queensland, Australia. High-severity cancers were defined as either Stage II-IV, Grade 3, or having negative hormone receptors at diagnosis. Logistic regression models were used to estimate odds ratios (ORs) of high severity BC for variables relating to screening, lifestyle, reproductive habits, family history, socioeconomic status, and area disadvantage. Results: Symptom-detected women had greater odds (OR 3.38, 2.86-4.00) of being diagnosed with high-severity cancer than screen-detected women. Women who did not have regular mammograms had greater odds (OR 1.78, 1.40-2.28) of being diagnosed with high-severity cancer than those who had mammograms biennially. This trend was significant in both screen-detected and symptom-detected women. Screen-detected women who were non-smokers (OR 1.77, 1.16-2.71), postmenopausal (OR 2.01, 1.42-2.84), or employed (OR 1.46, 1.15-1.85) had greater odds of being diagnosed with high-severity cancer than those who were current smokers, premenopausal, or unemployed. Symptom-detected women being overweight (OR 1.67, 1.31-2.14), postmenopausal (OR 2.01, 1.43-2.82), had hormone replacement therapy (HRT) < 2 years (OR 1.60, 1.02-2.51) had greater odds of being diagnosed with high-severity cancer than those of healthy weight, premenopausal, had HRT > 10 years. Conclusion: Screen-detected women and women who had mammograms biennially had lower odds of being diagnosed with high-severity breast cancer, which highlighted the benefit of regular breast cancer screening. Women in subgroups who are more likely to have more severe cancers should be particularly encouraged to participate in regular mammography screening.
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    Journal Title
    Breast Cancer Research and Treatment
    DOI
    https://doi.org/10.1007/s10549-020-05905-x
    Copyright Statement
    © 2020 Springer Netherlands. This is an electronic version of an article published in Breast Cancer Research and Treatment, 2020. Breast Cancer Research and Treatment is available online at: http://link.springer.com/ with the open URL of your article.
    Note
    This publication has been entered into Griffith Research Online as an Advanced Online Version.
    Subject
    Clinical Sciences
    Oncology and Carcinogenesis
    Breast cancer
    Mammograms screening
    Prognosis
    Risk factors
    Severity at diagnosis
    Publication URI
    http://hdl.handle.net/10072/397610
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