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dc.contributor.authorRafi, UM
dc.contributor.authorMahendiran, D
dc.contributor.authorKumar, RS
dc.contributor.authorRahiman, AK
dc.date.accessioned2020-09-17T23:14:59Z
dc.date.available2020-09-17T23:14:59Z
dc.date.issued2019
dc.identifier.issn0268-2605
dc.identifier.doi10.1002/aoc.4946
dc.identifier.urihttp://hdl.handle.net/10072/397624
dc.description.abstractThree heteroleptic copper(II) complexes of the type [Cu(L1–3)(cf)(ClO4)] (1–3), where cf = ciprofloxacin, have been synthesized using pyridazine-based ligands 3-chloro-6-(salicylidenehydrazinyl)pyridazine (HL1), 3-chloro-6-(4-diethylaminosalicylidenehydrazinyl)pyridazine (HL2) and 3-chloro-6-(5-bromosalicylidenehydrazinyl)pyridazine (HL3). Electronic spectral data and magnetic moment values suggest octahedral geometry for the synthesized copper(II) complexes. Electrochemical data of the copper(II) complexes present an irreversible one-electron reduction wave in the cathodic potential region (Epc) between −0.631 and −0.670 V. Frontier molecular orbital calculations were carried out, and the obtained low-energy gap supports the bio-efficacy of the complexes. All the complexes were screened for their in vitro cytotoxicity activity against three human cancerous (breast adenocarcinoma (MCF-7), hepatoma (HepG-2) and cervical (HeLa)) and one non-cancerous (non-tumorigenic human dermal fibroblast (NHDF)) cell lines using MTT assay, in which complex 2 exhibited higher activity. The apoptosis induction by the complexes was analysed using the Hoechst dye staining method with MCF-7 cell line, which indicates higher apoptotic activity of complex 2. A molecular docking study was carried out to ascertain the binding affinity of the synthesized heteroleptic copper(II) complexes with phosphoinositide 3-kinase gamma (PI3Kγ) receptor.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofpagefrome4946
dc.relation.ispartofissue7
dc.relation.ispartofjournalApplied Organometallic Chemistry
dc.relation.ispartofvolume33
dc.subject.fieldofresearchInorganic Chemistry
dc.subject.fieldofresearchOrganic Chemistry
dc.subject.fieldofresearchOther Chemical Sciences
dc.subject.fieldofresearchcode0302
dc.subject.fieldofresearchcode0305
dc.subject.fieldofresearchcode0399
dc.titleIn vitro anti-proliferative and in silico docking studies of heteroleptic copper(II) complexes of pyridazine-based ligands and ciprofloxacin
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationRafi, UM; Mahendiran, D; Kumar, RS; Rahiman, AK, In vitro anti-proliferative and in silico docking studies of heteroleptic copper(II) complexes of pyridazine-based ligands and ciprofloxacin, Applied Organometallic Chemistry, 2019, 33 (7), pp. e4946
dc.date.updated2020-09-17T22:08:03Z
gro.hasfulltextNo Full Text
gro.griffith.authorDharmasivam, Mahendiran


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