dc.contributor.author | Rafi, UM | |
dc.contributor.author | Mahendiran, D | |
dc.contributor.author | Kumar, RS | |
dc.contributor.author | Rahiman, AK | |
dc.date.accessioned | 2020-09-17T23:14:59Z | |
dc.date.available | 2020-09-17T23:14:59Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0268-2605 | |
dc.identifier.doi | 10.1002/aoc.4946 | |
dc.identifier.uri | http://hdl.handle.net/10072/397624 | |
dc.description.abstract | Three heteroleptic copper(II) complexes of the type [Cu(L1–3)(cf)(ClO4)] (1–3), where cf = ciprofloxacin, have been synthesized using pyridazine-based ligands 3-chloro-6-(salicylidenehydrazinyl)pyridazine (HL1), 3-chloro-6-(4-diethylaminosalicylidenehydrazinyl)pyridazine (HL2) and 3-chloro-6-(5-bromosalicylidenehydrazinyl)pyridazine (HL3). Electronic spectral data and magnetic moment values suggest octahedral geometry for the synthesized copper(II) complexes. Electrochemical data of the copper(II) complexes present an irreversible one-electron reduction wave in the cathodic potential region (Epc) between −0.631 and −0.670 V. Frontier molecular orbital calculations were carried out, and the obtained low-energy gap supports the bio-efficacy of the complexes. All the complexes were screened for their in vitro cytotoxicity activity against three human cancerous (breast adenocarcinoma (MCF-7), hepatoma (HepG-2) and cervical (HeLa)) and one non-cancerous (non-tumorigenic human dermal fibroblast (NHDF)) cell lines using MTT assay, in which complex 2 exhibited higher activity. The apoptosis induction by the complexes was analysed using the Hoechst dye staining method with MCF-7 cell line, which indicates higher apoptotic activity of complex 2. A molecular docking study was carried out to ascertain the binding affinity of the synthesized heteroleptic copper(II) complexes with phosphoinositide 3-kinase gamma (PI3Kγ) receptor. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Wiley | |
dc.relation.ispartofpagefrom | e4946 | |
dc.relation.ispartofissue | 7 | |
dc.relation.ispartofjournal | Applied Organometallic Chemistry | |
dc.relation.ispartofvolume | 33 | |
dc.subject.fieldofresearch | Inorganic chemistry | |
dc.subject.fieldofresearch | Organic chemistry | |
dc.subject.fieldofresearch | Other chemical sciences | |
dc.subject.fieldofresearchcode | 3402 | |
dc.subject.fieldofresearchcode | 3405 | |
dc.subject.fieldofresearchcode | 3499 | |
dc.title | In vitro anti-proliferative and in silico docking studies of heteroleptic copper(II) complexes of pyridazine-based ligands and ciprofloxacin | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Rafi, UM; Mahendiran, D; Kumar, RS; Rahiman, AK, In vitro anti-proliferative and in silico docking studies of heteroleptic copper(II) complexes of pyridazine-based ligands and ciprofloxacin, Applied Organometallic Chemistry, 2019, 33 (7), pp. e4946 | |
dc.date.updated | 2020-09-17T22:08:03Z | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Dharmasivam, Mahendiran | |