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  • Performance of AmpFire HPV assay on neck cervical lymph node aspirate and oropharyngeal samples

    Author(s)
    Jang, Dan
    Shah, Anika
    Arias, Manuel
    Ratnam, Sam
    Smieja, Marek
    Chen, Xin
    Wang, Youxiang
    Speicher, David J
    Chernesky, Max
    Griffith University Author(s)
    Speicher, David J.
    Year published
    2020
    Metadata
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    Abstract
    Early determination of high-risk human papillomaviruses causing oropharyngeal squamous cell carcinomas (OPSCC) may influence treatment. The objectives were to evaluate the performance of a new rapid isothermal nucleic acid amplification point of care HPV test (AmpFire HPV) on fine needle neck aspirates (FNA) of cervical lymph nodes and oropharyngeal swabs and saliva (OPS) which had been previously tested by the cobas HPV assay. The comparison was performed on 56 FNA and 81 OPS. The two assays showed strong agreement (94.6 %, K = 0.88) on FNA and fair agreement (65.4 %, K = 0.34) on OPS. AmpFire HPV performed on FNA demonstrated ...
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    Early determination of high-risk human papillomaviruses causing oropharyngeal squamous cell carcinomas (OPSCC) may influence treatment. The objectives were to evaluate the performance of a new rapid isothermal nucleic acid amplification point of care HPV test (AmpFire HPV) on fine needle neck aspirates (FNA) of cervical lymph nodes and oropharyngeal swabs and saliva (OPS) which had been previously tested by the cobas HPV assay. The comparison was performed on 56 FNA and 81 OPS. The two assays showed strong agreement (94.6 %, K = 0.88) on FNA and fair agreement (65.4 %, K = 0.34) on OPS. AmpFire HPV performed on FNA demonstrated a sensitivity of 76.7 % and specificity of 81.8 % for the prediction of p16 antigens in OPSCC with results available in 1.5 h.
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    Journal Title
    Journal of Virological Methods
    Volume
    279
    DOI
    https://doi.org/10.1016/j.jviromet.2020.113840
    Subject
    Microbiology
    Medical Microbiology
    Science & Technology
    Life Sciences & Biomedicine
    Biochemical Research Methods
    Biotechnology & Applied Microbiology
    Virology
    Publication URI
    http://hdl.handle.net/10072/397681
    Collection
    • Journal articles

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