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  • The First bla(KPC) Harboring Klebsiella pneumoniae ST258 Strain Isolated in Pakistan

    Author(s)
    Aslam, Bilal
    Chaudhry, Tamoor Hamid
    Arshad, Muhammad Imran
    Alvi, Roman Farooq
    Shahzad, Naveed
    Yasmeen, Nafeesa
    Idris, Adi
    Rasool, Muhammad Hidayat
    Khurshid, Mohsin
    Ma, Zhongren
    Call, Douglas R
    Baloch, Zulqarnain
    Griffith University Author(s)
    Idris, Adi
    Year published
    2020
    Metadata
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    Abstract
    Klebsiella pneumoniae is an important pathogen that causes pneumonia and bloodstream infections, especially in neonates and intensive care patients. The carbapenems remain an important therapeutic option for clinicians, particularly against cephalosporin-resistant Gram-negative pathogens. This increased use of carbapenems at clinics has resulted in the evolution and spread of carbapenem-resistant K. pneumoniae. In this study, we isolated six bla K. pneumoniae carbapenemase (KPC)-producing strains belonging to sequence type 258 (ST258) from clinical, environmental, and veterinary sources. Antibiotic susceptibility was performed ...
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    Klebsiella pneumoniae is an important pathogen that causes pneumonia and bloodstream infections, especially in neonates and intensive care patients. The carbapenems remain an important therapeutic option for clinicians, particularly against cephalosporin-resistant Gram-negative pathogens. This increased use of carbapenems at clinics has resulted in the evolution and spread of carbapenem-resistant K. pneumoniae. In this study, we isolated six bla K. pneumoniae carbapenemase (KPC)-producing strains belonging to sequence type 258 (ST258) from clinical, environmental, and veterinary sources. Antibiotic susceptibility was performed on these isolates and the genes responsible for extended-spectrum beta-lactamases and metallo-beta-lactamase production were screened. The molecular typing was done using multilocus sequence typing. Isolated strains were resistant to various antibiotic classes, including carbapenems, and carried the carbapenem-resistant gene, blaKPC. All strains were susceptible to tigecycline and colistin. This is the first report detecting K. pneumoniae ST258 strains in Pakistan.
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    Journal Title
    Microbial Drug Resistance
    Volume
    26
    Issue
    7
    DOI
    https://doi.org/10.1089/mdr.2019.0420
    Subject
    Biological Sciences
    Agricultural and Veterinary Sciences
    Medical and Health Sciences
    Science & Technology
    Life Sciences & Biomedicine
    Infectious Diseases
    Microbiology
    Pharmacology & Pharmacy
    Publication URI
    http://hdl.handle.net/10072/397690
    Collection
    • Journal articles

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