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dc.contributor.authorAslam, Bilal
dc.contributor.authorChaudhry, Tamoor Hamid
dc.contributor.authorArshad, Muhammad Imran
dc.contributor.authorAlvi, Roman Farooq
dc.contributor.authorShahzad, Naveed
dc.contributor.authorYasmeen, Nafeesa
dc.contributor.authorIdris, Adi
dc.contributor.authorRasool, Muhammad Hidayat
dc.contributor.authorKhurshid, Mohsin
dc.contributor.authorMa, Zhongren
dc.contributor.authorCall, Douglas R
dc.contributor.authorBaloch, Zulqarnain
dc.description.abstractKlebsiella pneumoniae is an important pathogen that causes pneumonia and bloodstream infections, especially in neonates and intensive care patients. The carbapenems remain an important therapeutic option for clinicians, particularly against cephalosporin-resistant Gram-negative pathogens. This increased use of carbapenems at clinics has resulted in the evolution and spread of carbapenem-resistant K. pneumoniae. In this study, we isolated six bla K. pneumoniae carbapenemase (KPC)-producing strains belonging to sequence type 258 (ST258) from clinical, environmental, and veterinary sources. Antibiotic susceptibility was performed on these isolates and the genes responsible for extended-spectrum beta-lactamases and metallo-beta-lactamase production were screened. The molecular typing was done using multilocus sequence typing. Isolated strains were resistant to various antibiotic classes, including carbapenems, and carried the carbapenem-resistant gene, blaKPC. All strains were susceptible to tigecycline and colistin. This is the first report detecting K. pneumoniae ST258 strains in Pakistan.
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofjournalMicrobial Drug Resistance
dc.subject.fieldofresearchBiological Sciencesen_US
dc.subject.fieldofresearchAgricultural and Veterinary Sciencesen_US
dc.subject.fieldofresearchMedical and Health Sciencesen_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsInfectious Diseasesen_US
dc.subject.keywordsPharmacology & Pharmacyen_US
dc.titleThe First bla(KPC) Harboring Klebsiella pneumoniae ST258 Strain Isolated in Pakistan
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationAslam, B; Chaudhry, TH; Arshad, MI; Alvi, RF; Shahzad, N; Yasmeen, N; Idris, A; Rasool, MH; Khurshid, M; Ma, Z; Call, DR; Baloch, Z, The First bla(KPC) Harboring Klebsiella pneumoniae ST258 Strain Isolated in Pakistan, Microbial Drug Resistance, 2020, 26 (7), pp. 783-786
gro.hasfulltextNo Full Text
gro.griffith.authorIdris, Adi

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