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dc.contributor.authorGavin, Nicole C
dc.contributor.authorKleidon, Tricia M
dc.contributor.authorLarsen, Emily
dc.contributor.authorO'Brien, Catherine
dc.contributor.authorUllman, Amanda
dc.contributor.authorNorthfield, Sarah
dc.contributor.authorMihala, Gabor
dc.contributor.authorRunnegar, Naomi
dc.contributor.authorMarsh, Nicole
dc.contributor.authorRickard, Claire M
dc.date.accessioned2020-09-22T04:51:34Z
dc.date.available2020-09-22T04:51:34Z
dc.date.issued2020
dc.identifier.issn1745-6215
dc.identifier.doi10.1186/s13063-020-04699-z
dc.identifier.urihttp://hdl.handle.net/10072/397778
dc.description.abstractBACKGROUND: To evaluate the feasibility of an efficacy trial comparing a hydrophobic polyurethane peripherally inserted central catheter (PICC) with a standard polyurethane PICC. METHODS: This pilot randomised controlled trial (RCT) was conducted between May 2017 and February 2018. Adult participants (n = 111) were assigned to hydrophobic polyurethane PICC with proximal valve (intervention) or a polyurethane PICC with external clamp (standard care). Primary outcome was trial feasibility including PICC failure. Secondary outcomes were central line-associated bloodstream infection, local infection, occlusion, thrombosis, fracture and dislodgement, phlebitis, local or systemic allergic reaction, and PICC dwell time. RESULTS: All feasibility outcomes were achieved, apart from eligibility criteria. In total, 338 patients were screened, 138 were eligible (41%), and of these 111 were randomised (80%). Patients received the allocated PICC in 106 (95%) insertions. No patients withdrew from the study and there was no missing data. PICC failure was 24% (13/55) in the intervention group and 22% (12/55) in the standard care group (p = 0.820). PICC failure per 1000 PICC days was 16.3 in the intervention group and 18.4 in the control group (p = 0.755). The average dwell time was 12 days in the intervention and 8 days in the control group. CONCLUSIONS: This study demonstrates the feasibility of an efficacy trial of PICC materials in an adult population, once adjustments were made to include not only in-patients, but also patients being discharged to the Hospital in the Home service. TRIAL REGISTRATION: Australia and New Zealand Clinical Trials Registry ACTRN12616001578493 . Prospectively registered on 16 November 2016. The trial protocol was published a priori (Kleidon et al., Vasc Access 3:15-21, 2017).
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofpagefrom787
dc.relation.ispartofissue1
dc.relation.ispartofjournalTrials
dc.relation.ispartofvolume21
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3201
dc.subject.fieldofresearchcode3202
dc.subject.keywordsFeasibility
dc.subject.keywordsHydrophobic polyurethane
dc.subject.keywordsPICC failure
dc.subject.keywordsPeripherally inserted central catheter (PICC)
dc.subject.keywordsPilot randomised controlled trial
dc.titleA comparison of hydrophobic polyurethane and polyurethane peripherally inserted central catheter: results from a feasibility randomized controlled trial.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationGavin, NC; Kleidon, TM; Larsen, E; O'Brien, C; Ullman, A; Northfield, S; Mihala, G; Runnegar, N; Marsh, N; Rickard, CM, A comparison of hydrophobic polyurethane and polyurethane peripherally inserted central catheter: results from a feasibility randomized controlled trial., Trials, 2020, 21 (1), pp. 787
dcterms.dateAccepted2020-08-24
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-09-22T03:10:39Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s). 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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gro.griffith.authorLarsen, Emily N.


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