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  • Atmospheric pressure plasma treatments protect neural cells from ischemic stroke-relevant injuries by targeting mitochondria

    Author(s)
    Yan, Xu
    Zhang, Chenyang
    Ouyang, Jiting
    Shi, Zhongfang
    Chen, Ye
    Han, Ruoyu
    Zhang, Wei
    Yuan, Fang
    Ostrikov, Kostya Ken
    Griffith University Author(s)
    Ostrikov, Ken
    Year published
    2020
    Metadata
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    Abstract
    Most studies regarding plasma biomedicine applications mainly focus on the oxidative and/or nitrative stress on bacteria, cancer cells, and other treatment objects. In this study, we evaluate the protective effect of appropriate atmospheric pressure plasma jet (APPJ) treatments on oxygen and glucose deprivation (OGD)‐induced neural cell apoptosis, which is a major pathological process during ischemic stroke, based on the physiological functions of NO. Results show that APPJ treatment reduces the OGD‐induced apoptosis by weakening typical OGD injury consequences including loss of mitochondrial membrane potential, the release ...
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    Most studies regarding plasma biomedicine applications mainly focus on the oxidative and/or nitrative stress on bacteria, cancer cells, and other treatment objects. In this study, we evaluate the protective effect of appropriate atmospheric pressure plasma jet (APPJ) treatments on oxygen and glucose deprivation (OGD)‐induced neural cell apoptosis, which is a major pathological process during ischemic stroke, based on the physiological functions of NO. Results show that APPJ treatment reduces the OGD‐induced apoptosis by weakening typical OGD injury consequences including loss of mitochondrial membrane potential, the release of cytochrome c from the mitochondria into the cytoplasm, lower antiapoptotic Bcl‐2 expression, and upregulating the proapoptotic protein Bax. Furthermore, APPJ increased intracellular NO production, which is closely related to the cytoprotective effect of APPJ.
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    Journal Title
    Plasma Processes and Polymers
    DOI
    https://doi.org/10.1002/ppap.202000063
    Note
    This publication has been entered in Griffith Research Online as an advanced online version.
    Subject
    Atomic, molecular and optical physics
    Nuclear and plasma physics
    Particle and high energy physics
    Physical chemistry
    Materials engineering
    Science & Technology
    Physical Sciences
    Physics, Applied
    Physics, Fluids & Plasmas
    Physics, Condensed Matter
    Publication URI
    http://hdl.handle.net/10072/397820
    Collection
    • Journal articles

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