dc.contributor.author | Bharathi, S | |
dc.contributor.author | Mahendiran, D | |
dc.contributor.author | Senthil Kumar, R | |
dc.contributor.author | Kalilur Rahiman, A | |
dc.date.accessioned | 2020-09-29T01:52:31Z | |
dc.date.available | 2020-09-29T01:52:31Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2365-6549 | |
dc.identifier.doi | 10.1002/slct.202000911 | |
dc.identifier.uri | http://hdl.handle.net/10072/398005 | |
dc.description.abstract | Six heteroleptic oxovanadium(IV) complexes with general formula [VOL1–6(nap)], where, L1–3=2-(1-(4-substitutedphenyl)ethylidene)hydrazinecarbothioamide, L4–6=2-(1-(4-substitutedphenyl)ethylidene)-N-methylhydrazinecarbothioamide and nap=naproxen, have been synthesized and characterized. FTIR spectra exhibit a strong band between 965 and 991 cm−1, characteristic of υ(V=O) stretching vibration. UV-Vis and theoretical studies suggested distorted square-pyramidal geometry and oxidation state of vanadium(IV) with d1 configuration was confirmed by EPR spectra. Cyclic voltammograms exhibit metal based irreversible redox peaks corresponding to one electron oxidation (+0.83 to +0.70 V) and reduction (−0.69 to −0.53 V) processes. In vitro antioxidant studies revealed that complexes containing electron donating substituent (−CH3) showed higher activity. In vitro antidiabetic activity of complexes with enzymes like α-amylase, α-glucosidase and glucose-6-phosphatase made them better inhibitors of insulin, which is further supported by in silico studies, and complex 6 shows better in vitro insulin mimic activity against insulin responsive 3T3-L1 adipocyte cells compared to insulin and metformin. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Wiley | |
dc.relation.ispartofpagefrom | 6245 | |
dc.relation.ispartofpageto | 6254 | |
dc.relation.ispartofissue | 21 | |
dc.relation.ispartofjournal | ChemistrySelect | |
dc.relation.ispartofvolume | 5 | |
dc.subject.fieldofresearch | Chemical sciences | |
dc.subject.fieldofresearchcode | 34 | |
dc.title | In Vitro Antioxidant and Insulin Mimetic Activities of Heteroleptic Oxovanadium(IV) Complexes with Thiosemicarbazones and Naproxen | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Bharathi, S; Mahendiran, D; Senthil Kumar, R; Kalilur Rahiman, A, In Vitro Antioxidant and Insulin Mimetic Activities of Heteroleptic Oxovanadium(IV) Complexes with Thiosemicarbazones and Naproxen, ChemistrySelect, 2020, 5 (21), pp. 6245-6254 | |
dc.date.updated | 2020-09-29T01:49:02Z | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Dharmasivam, Mahendiran | |