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dc.contributor.authorBharathi, S
dc.contributor.authorMahendiran, D
dc.contributor.authorSenthil Kumar, R
dc.contributor.authorKalilur Rahiman, A
dc.date.accessioned2020-09-29T01:52:31Z
dc.date.available2020-09-29T01:52:31Z
dc.date.issued2020
dc.identifier.issn2365-6549
dc.identifier.doi10.1002/slct.202000911
dc.identifier.urihttp://hdl.handle.net/10072/398005
dc.description.abstractSix heteroleptic oxovanadium(IV) complexes with general formula [VOL1–6(nap)], where, L1–3=2-(1-(4-substitutedphenyl)ethylidene)hydrazinecarbothioamide, L4–6=2-(1-(4-substitutedphenyl)ethylidene)-N-methylhydrazinecarbothioamide and nap=naproxen, have been synthesized and characterized. FTIR spectra exhibit a strong band between 965 and 991 cm−1, characteristic of υ(V=O) stretching vibration. UV-Vis and theoretical studies suggested distorted square-pyramidal geometry and oxidation state of vanadium(IV) with d1 configuration was confirmed by EPR spectra. Cyclic voltammograms exhibit metal based irreversible redox peaks corresponding to one electron oxidation (+0.83 to +0.70 V) and reduction (−0.69 to −0.53 V) processes. In vitro antioxidant studies revealed that complexes containing electron donating substituent (−CH3) showed higher activity. In vitro antidiabetic activity of complexes with enzymes like α-amylase, α-glucosidase and glucose-6-phosphatase made them better inhibitors of insulin, which is further supported by in silico studies, and complex 6 shows better in vitro insulin mimic activity against insulin responsive 3T3-L1 adipocyte cells compared to insulin and metformin.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofpagefrom6245
dc.relation.ispartofpageto6254
dc.relation.ispartofissue21
dc.relation.ispartofjournalChemistrySelect
dc.relation.ispartofvolume5
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchcode34
dc.titleIn Vitro Antioxidant and Insulin Mimetic Activities of Heteroleptic Oxovanadium(IV) Complexes with Thiosemicarbazones and Naproxen
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBharathi, S; Mahendiran, D; Senthil Kumar, R; Kalilur Rahiman, A, In Vitro Antioxidant and Insulin Mimetic Activities of Heteroleptic Oxovanadium(IV) Complexes with Thiosemicarbazones and Naproxen, ChemistrySelect, 2020, 5 (21), pp. 6245-6254
dc.date.updated2020-09-29T01:49:02Z
gro.hasfulltextNo Full Text
gro.griffith.authorDharmasivam, Mahendiran


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