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dc.contributor.authorLam, Alfred King-Yin
dc.date.accessioned2020-10-06T02:43:28Z
dc.date.available2020-10-06T02:43:28Z
dc.date.issued2020
dc.identifier.issn1351-0088en_US
dc.identifier.doi10.1530/ERC-20-0045en_US
dc.identifier.urihttp://hdl.handle.net/10072/398035
dc.description.abstractThe aim is to review the features of 117 primary squamous cell carcinomas of thyroid which meet the histological criteria of the World Health Organization classification of endocrine tumours. The carcinomas occur in 83 women and 34 men (female to male ratio is 2.4 to 1) and with median age at presentation of 64. Half of these squamous cell carcinomas of thyroid were moderately differentiated. PAX-8 protein is a sensitive marker for confirming the thyroid origin of the carcinoma. The carcinoma is also positive for p63, p40, cytokeratins 5/6, 7,19 and negative for cytokeratins 20 and 10/13. P53 overexpression is common. The most important differential diagnosis is direct infiltration or metastatic involvement by squamous cell carcinoma from other organs. Limited mutation analysis revealed BRAF mutation in some squamous cell carcinomas of the thyroid. The genetic profile appears to be different from anaplastic thyroid carcinomas. Primary squamous cell carcinoma of thyroid had lymph node involvement in 59% and distant metastases in 26%. The median survival of the patients was 8 months. Curative surgery offers the best survival for the patients with the carcinoma. To conclude, primary squamous cell carcinoma of the thyroid gland has distinctive clinical, pathological and molecular profiles. It is important to recognize this unique variant of thyroid carcinoma for possible curative surgical resection and to do more genomic works on the entity to uncover the molecular pathogenesis.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherSociety for Endocrinologyen_US
dc.relation.ispartofpagefromR177en_US
dc.relation.ispartofpagetoR192en_US
dc.relation.ispartofissue6en_US
dc.relation.ispartofjournalEndocrine-Related Cancer (ERC)en_US
dc.relation.ispartofvolume27en_US
dc.subject.fieldofresearchBiological Sciencesen_US
dc.subject.fieldofresearchMedical and Health Sciencesen_US
dc.subject.fieldofresearchcode06en_US
dc.subject.fieldofresearchcode11en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsOncologyen_US
dc.subject.keywordsEndocrinology & Metabolismen_US
dc.subject.keywordssquamous carcinomaen_US
dc.titleSquamous cell carcinoma of thyroid: a unique type of cancer in World Health Organization Classificationen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationLam, AK-Y, Squamous cell carcinoma of thyroid: a unique type of cancer in World Health Organization Classification, Endocrine-Related Cancer (ERC), 2020, 27 (6), pp. R177-R192en_US
dcterms.dateAccepted2020-04-05
dc.date.updated2020-09-30T01:44:12Z
dc.description.versionAccepted Manuscript (AM)en_US
gro.rights.copyrightDisclaimer. This is not the definitive version of record of this article. This manuscript has been accepted for publication in Endocrine-Related Cancer, but the version presented here has not yet been copy edited, formatted or proofed. Consequently, the Society for Endocrinology accepts no responsibility for any errors or omissions it may contain. Copyright 2020 Society for Endocrinology. Please refer to the journal's website for access to the definitive, published version.en_US
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gro.griffith.authorLam, Alfred K.


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