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dc.contributor.authorNeale, Peta A
dc.contributor.authorBraun, Georg
dc.contributor.authorBrack, Werner
dc.contributor.authorCarmona, Eric
dc.contributor.authorGunold, Roman
dc.contributor.authorKoenig, Maria
dc.contributor.authorKrauss, Martin
dc.contributor.authorLiebmann, Liana
dc.contributor.authorLiess, Matthias
dc.contributor.authorLink, Moritz
dc.contributor.authorSchaefer, Ralf B
dc.contributor.authorSchlichting, Rita
dc.contributor.authorSchreiner, Verena C
dc.contributor.authorEscher, Beate
dc.contributor.authoret al.
dc.date.accessioned2020-10-01T03:42:34Z
dc.date.available2020-10-01T03:42:34Z
dc.date.issued2020
dc.identifier.issn0013-936X
dc.identifier.doi10.1021/acs.est.0c02235
dc.identifier.urihttp://hdl.handle.net/10072/398047
dc.description.abstractRain events may impact the chemical pollution burden in rivers. Forty-four small streams in Germany were profiled during several rain events for the presence of 395 chemicals and five types of mixture effects in in vitro bioassays (cytotoxicity; activation of the estrogen, aryl hydrocarbon, and peroxisome proliferator-activated receptors; and oxidative stress response). While these streams were selected to cover a wide range of agricultural impacts, in addition to the expected pesticides, wastewater-derived chemicals and chemicals typical for street runoff were detected. The unexpectedly high estrogenic effects in many samples indicated the impact by wastewater or overflow of combined sewer systems. The 128 water samples exhibited a high diversity of chemical and effect patterns, even for different rain events at the same site. The detected 290 chemicals explained only a small fraction (<8%) of the measured effects. The experimental effects of the designed mixtures of detected chemicals that were expected to dominate the mixture effects of detected chemicals were consistent with predictions for concentration addition within a factor of two for 94% of the mixtures. Overall, the burden of chemicals and effects was much higher than that previously detected in surface water during dry weather, with the effects often exceeding proposed effect-based trigger values.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society (ACS Publications)
dc.relation.ispartofpagefrom8280
dc.relation.ispartofpageto8290
dc.relation.ispartofissue13
dc.relation.ispartofjournalEnvironmental Science & Technology
dc.relation.ispartofvolume54
dc.subject.fieldofresearchEnvironmental sciences
dc.subject.fieldofresearchcode41
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsEngineering, Environmental
dc.titleAssessing the Mixture Effects in In Vitro Bioassays of Chemicals Occurring in Small Agricultural Streams during Rain Events
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationNeale, PA; Braun, G; Brack, W; Carmona, E; Gunold, R; Koenig, M; Krauss, M; Liebmann, L; Liess, M; Link, M; Schaefer, RB; Schlichting, R; Schreiner, VC; Schulze, T; Vormeier, P; Weisner, O; Escher, B, Assessing the Mixture Effects in In Vitro Bioassays of Chemicals Occurring in Small Agricultural Streams during Rain Events, Environmental Science & Technology, 2020, 54 (13), pp. 8280-8290
dc.date.updated2020-09-30T04:15:07Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyrightThis document is the Postprint: Accepted Manuscript version of a Published Work that appeared in final form in Environmental Science & Technology, © 2020 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.est.0c02235
gro.hasfulltextFull Text
gro.griffith.authorNeale, Peta A.
gro.griffith.authorEscher, Beate


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